Description:
Project ID: D2019-15
Background
Rheumatoid Arthritis (RA) is an autoimmune disease that causes swelling of the joints. Treatments are limited to anti-inflammatories, DMARDs, corticosteroids or biologics. Genetic research has identified several genetic factors that determine susceptibility to developing RA. However, there are no prophylactics or therapeutics to prevent or reverse the disease.
Invention Description
14-3-3 is a family of proteins with antigens in autoimmune diseases, cancers, and infectious disease. Researchers at the University of Toledo have shown that immunization with isoform 14-3-3 zeta is protective in the Pristane Induced Arthritis Model.
Applications
• Preventing, treating, or delaying the onset of RA
• Modulating IL-17A, IFN-g
• Promoting growth of PBMCs, T Cell differentiation, and cytokine excretion
Advantages
• Can be used as a vaccine to prevent arthritis
IP Status: Patent pending
Publication: McGowan J, Peter C, Chattopadhyay S and Chakravarti R (2019) 14-3-3ζ-A Novel Immunogen Promotes Inflammatory Cytokine Production. Front. Immunol. 10:1553. doi: 10.3389/fimmu.2019.01553