Therapeutic and Prophylactic for Arthritis

Description:

Project ID:  D2019-15

 

Background

Rheumatoid Arthritis (RA) is an autoimmune disease that causes swelling of the joints. Treatments are limited to anti-inflammatories, DMARDs, corticosteroids or biologics. Genetic research has identified several genetic factors that determine susceptibility to developing RA. However, there are no prophylactics or therapeutics to prevent or reverse the disease. 

 

Invention Description

14-3-3 is a family of proteins with antigens in autoimmune diseases, cancers, and infectious disease. Researchers at the University of Toledo have shown that immunization with isoform 14-3-3 zeta is protective in the Pristane Induced Arthritis Model.

 

Applications

•       Preventing, treating, or delaying the onset of RA

•       Modulating IL-17A, IFN-g

•       Promoting growth of PBMCs, T Cell differentiation, and cytokine excretion

 

Advantages

•       Can be used as a vaccine to prevent arthritis

 

IP Status:       Patent pending

 

Patent Information:
Category(s):
Therapeutics
For Information, Contact:
Katherine Pollard
Licensing Associate
The University of Toledo
419-530-6228
katherine.pollard@utoledo.edu
Inventors:
Ritu Chakravarti
Bina Joe
Keywords:
14-3-3z, 14-3-3 zeta
Arthritis
Autoimmune