Latest technologies from The University of Toledohttp://utoledo.technologypublisher.comBe the first to know about the latest inventions and technologies available from The University of Toledoen-USFri, 22 Sep 2017 06:12:30 GMTMon, 14 Aug 2017 05:51:19 GMT 2017, The University of ToledoMuscarinic Agonists for the Treatment of Autism Spectrum Disorder, 14 Aug 2017 05:51:19 GMTsandy.rhoades@utoledo.edu as Novel Therapeutics for Neurodegenerative Disorders, 06 Mar 2017 09:36:24 GMTsandy.rhoades@utoledo.edu Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens, 06 Mar 2017 08:04:10 GMTsandy.rhoades@utoledo.edu of Small Molecule Inhibitors as Anti-Thrombotic Agents D2016-03IP Status: Provisional filed Invention Description: Discovery of a new family of small molecules that can be used to decrease the risk of thrombosis in patients with several diseases. Novelty: The most important aspect of this new antithrombotic is that it prevents the transition of platelets to a hypersensitive state without impacting normal hemostatic responses. Current therapies target major platelet activation pathways while our molecule targets a specific pathway only involved in hypersensitivity but not in coagulation. Treating patients with conditions such as systemic l...Wed, 21 Dec 2016 09:26:18 GMTsandy.rhoades@utoledo.edu Cost- and Energy-Efficient Device for De-watering Microalgae Using Stimuli-Sensitive Hydrogels, 21 Dec 2016 09:17:50 GMTsandy.rhoades@utoledo.edu Treatment for Raynaud’s Phenomenon Targets Cold Receptor, 09 Nov 2016 07:45:01 GMTsandy.rhoades@utoledo.edu (5H10) Monoclonal Antibody, 10 Oct 2016 07:23:02 GMTsandy.rhoades@utoledo.edu Immuno-oncology--Tn-specific monoclonal IgM antibody binds and kills human tumor cells, 21 Sep 2016 10:24:31 GMTsandy.rhoades@utoledo.edu preparation of stiff gel adhesives, sealants, and sustained release devices for underwater use, 01 Sep 2016 07:00:23 GMTsandy.rhoades@utoledo.edu monoclonal antibody 1G6D2, 30 Aug 2016 06:27:14 GMTsandy.rhoades@utoledo.edu monoclonal antibody 3A3E1, 30 Aug 2016 06:22:23 GMTsandy.rhoades@utoledo.edu monoclonal antibody 6E11A4, 30 Aug 2016 06:19:47 GMTsandy.rhoades@utoledo.edu Species-Selective Antimicrobials to Thwart Developing Resistance ID: D2015-58IP Status: Provisional patent application # 62/212,149Invention Description and Novelty: Drug resistance limits the effectiveness of most currently used antimicrobial agents. Infectious organisms are becoming resistant to even the most recently developed antimicrobials that target essential steps in cell wall assembly and protein biosynthesis. Researchers at The University of Toledo have created new antimicrobials with unique modes of action against a new drug target.Applications: Compounds and methods for developing new antimicrobials that are species-selective and act thr...Wed, 13 Jul 2016 06:36:28 GMTsandy.rhoades@utoledo.edu Antibacterial Agents against Mycobacterium Tuberculosis and other Mycobacterium Species, 06 Jul 2016 11:40:15 GMTsandy.rhoades@utoledo.edu to Develop Compounds for Treating Canavan Disease ID: D2016-26IP Status: Provisional patent application #62/216,700Invention Description and Novelty: Canavan disease is a neurological disease caused by an interruption in the metabolism of N-acetylaspartate (NAA). Numerous mutations have been found in the enzyme that hydrolyzes NAA, and the catalytic activity of aspartoacylase is significantly impaired in CD patients. It is believed that the enzyme that catalyzes the synthesis of NAA in the brain plays an important role in CD. However, prior attempts to express and purify this enzyme have not succeeded in obtaining a soluble, stable, a...Tue, 05 Jul 2016 12:58:29 GMTsandy.rhoades@utoledo.edu“Thin” Molecules for Treating Obesity and Type II Diabetes, 07 Apr 2016 08:57:10 GMTsandy.rhoades@utoledo.edu Platform for Three-Dimensional Tissue Engineering Scaffolds, 06 Apr 2016 12:50:02 GMTsandy.rhoades@utoledo.edu“Sweet-P”: Molecule for Targeting Human Glucocorticoid Receptor Beta in Cancer, 06 Apr 2016 12:34:39 GMTsandy.rhoades@utoledo.edu to Produce High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Implants and Hardware, 10 Feb 2016 13:01:21 GMTsandy.rhoades@utoledo.edu Bi-level Equalizer for Battery Cell Charge Management, 10 Feb 2016 12:40:29 GMTsandy.rhoades@utoledo.edu family of trianionic ligand precursors provide unprecedented control over polymer properties, 02 Dec 2015 07:12:15 GMTsandy.rhoades@utoledo.edu approach to deposit bone-like coating on PEEK and other materials to improve osteoconductivity in implants ID: D2011-33IP Status: Patent Pending U.S and EuropeInvention Description: Novel method to prepare an implantable article comprised of a biocompatible substrate (polymeric or ceramic) to accept a very thin biocompatible, bioactive coating material to facilitate bio-ingrowth between the substrate and bone or cartilage tissue.Applications: Bone fractures treated with wires, nails, screws, and plates; joints replaced by artificial endoprostheses; dental implants; other.Novelty: Uses microwave energy to form a carbonated calcium deficient hydroxyapatite (CDHA) layer on the surface of impla...Wed, 02 Dec 2015 07:09:33 GMTsandy.rhoades@utoledo.edu of Stable iTregs as Therapeutics against Autoimmune Diseases (Type I Diabetes), 06 Jul 2015 11:53:54 GMTsandy.rhoades@utoledo.edu Metathesis Creates Nylon-11, -12 and -13 Precursors from Widely Abundant Plant-Derived Biomass Project ID: D2014-39 IP Status: Provisional patent #62/020,488 filed Invention Description: Invention relates to a new ring-closing-metathesis approach for making C11, C12 and C13 lactams (cyclic form of amino acids) from oleic acid or alkyl esters originating from lipids. The method allows direct conversion of the widely abundant natural fatty acid oleic acid into synthetic precursors of nylon-11, -12 and -13 in fewer steps than previously developed methods. Applications: Applications include automotive, transportation, sports, medical, high-performance cables, electronics, electrical compo...Thu, 18 Jun 2015 12:52:30 GMTsandy.rhoades@utoledo.edu for Production of Fatty Acid Alkanolamides (FAAAs) from Microalgae Biomass, 18 Jun 2015 12:52:29 GMTsandy.rhoades@utoledo.edu Alternatives to Petroleum-Derived Products: Novel Approach Creates Nylon-12 and -13 Precursors from Lipids Project ID: D2014-06 Invention Description: Invention relates to a new olefin cross-metathesis approach for making C12 and C13 amino esters from oleic acid (or alkyl esters) originating from lipids. The method allows direct conversion of the widely abundant natural fatty acid oleic acid into synthetic precursors or nylon-12 and nylon-13 in half the steps than previously developed methods. Applications: Applications include automotive, transportation, sports, medical, high-performance cables, electronics, electrical compounds, photovoltaic panels, and even lenses for glasses. Novelty: Effic...Thu, 18 Jun 2015 12:52:28 GMTsandy.rhoades@utoledo.edu of fluorescent ANTS to examine the BBB-permeability of polysaccharide, 17 Jun 2015 11:37:27 GMTsandy.rhoades@utoledo.edu agents and methods for treating neurodegenerative disorders, 17 Jun 2015 11:37:25 GMTsandy.rhoades@utoledo.edu agents and methods for treating metabolic bone disorders and other conditions, 17 Jun 2015 11:06:24 GMTsandy.rhoades@utoledo.edu (4A2) Monoclonal Antibody, 02 Jun 2015 12:20:03 GMTsandy.rhoades@utoledo.edu HDAC Inhibitors as Anti-Cancer Agents, 14 May 2015 12:02:34 GMTsandy.rhoades@utoledo.edu New Therapeutics for Ischemic Stroke, 07 Apr 2015 06:45:11 GMTsandy.rhoades@utoledo.edu Laryngeal Mechanosensor Stimulator, 05 Feb 2015 10:20:15 GMTsandy.rhoades@utoledo.edu Drug-Like Molecules as Anticancer Agents Selective for Cancer Stem Cells Project ID: D2013-04 Novelty: A new class of anticancer agents which are highly selective for mesenchymal cancer cells with stem cell like properties. Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the same time, tumors are heterogeneous and current evidence suggests that a subpopulation of tumor cells, called tumor initiating or cancer stem cells are responsible for metastatic dissemination, tumor relapse and possibly drug resistance. Classical apoptotic drugs are less effective agai...Tue, 03 Feb 2015 10:22:31 GMTsandy.rhoades@utoledo.edu in Platinum Based Cancer Therapeutics Project ID: D2014-33 Novelty: Small drug like molecules that inhibits DNA repair factors for cisplatin (and other platinum based drugs) resistance towards solid tumors, thereby increasing cisplatin cytotoxicity and efficacy. Value proposition: One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer cells. Although increased DNA repair has been shown to be a major mechanism of cancer drug resistance, not much was done until recently to address this challenge. The researchers at The University of Toledo have discovered small drug like molecules...Tue, 19 Aug 2014 08:26:50 GMTsandy.rhoades@utoledo.edu Magnesium/Rare Earth Alloys for Biomedical Implants, 28 Jul 2014 08:19:00 GMTsandy.rhoades@utoledo.edu Biodegradable Bone Matrix for Multiple Myeloma Lesion Augmentation and Osteoporosis, 28 Jul 2014 08:09:30 GMTsandy.rhoades@utoledo.edu Spinal Deformity Correction Device for Children and Adolescents Project ID: D2009-90 Invention Description: Patented technology combines a hybrid rod-cable that loops around rotatory pedicle screws anchored to the proximal-most vertebrae within the spinal deformity to correct scoliosis. The device may be placed in any region of the spine, but is typically located in the thoracic or lumbar regions. Growth and elongation of the spinal column on the convex side of the curve is exploited to correct growth inequality between the two sides. The construct has four different components--fixed, intermediate, and rotatory anchors plus a unitized cable for anchorin...Mon, 21 Jul 2014 06:33:16 GMTsandy.rhoades@utoledo.edu Spinal Fixation Hook, 15 Jul 2014 12:38:28 GMTsandy.rhoades@utoledo.edu pedicle screw, 15 Jul 2014 12:31:20 GMTsandy.rhoades@utoledo.edu Screw Including Stationary and Movable Members for Surgical Correction of Spinal Deformities, 15 Jul 2014 12:05:31 GMTsandy.rhoades@utoledo.edu Fixation Assembly for Spinal Column, 15 Jul 2014 06:26:18 GMTsandy.rhoades@utoledo.edu Pedicle Screw Assembly for Minimally Invasive Surgery, 14 Jul 2014 13:23:25 GMTsandy.rhoades@utoledo.edu Molecule to Modulate Skin Pigmentation, 21 May 2014 08:02:05 GMTsandy.rhoades@utoledo.edu Endothelial Specific TRPC3 Transgenic Mouse Project: D2012-18 Strains: EST3Tg/C57BL6 and EST3Tg/Apoe-/- Type: Humanized transgenic mouse Background: In the U.S., atherosclerosis, hypertension and stroke are the major causes of death due to cardiovascular disease and remain most frequent vascular complications of metabolic diseases such as diabetes, obesity and metabolic syndrome. A common signature of the associated vascular pathology is the presence of a dysfunctional endothelium, endothelial inflammation and/or changes in endothelial integrity. Research over the last fifteen years led to identification of members of the Transient Re...Mon, 07 Apr 2014 12:36:21 GMTsandy.rhoades@utoledo.edu Fluorescent Probe and Assay for Quantifying Adenosine and Adenosyl-Containing Compounds in Solution, 04 Apr 2014 12:46:52 GMTsandy.rhoades@utoledo.edu of Making and Using Antibacterial Surfactant/Microgel Formulations Project ID: D2012-31 Invention Description and Novelty: Antibacterial surfactant formulations are often prepared using cationic surfactants (e.g., alkyltrimethylammonium salts) which are toxic. Consequently, their use in cleaning and disinfecting formulations raises environmental and health concerns. Unique formulations consisting of quaternized microgels and a surfactant have been developed for personal care; or household, hospital, and industrial cleaning. These bio-based formulations exhibit high antimicrobial activity, thus allowing for the use of low concentrations of the active agents t...Thu, 27 Mar 2014 10:20:21 GMTsandy.rhoades@utoledo.edu area thin-film photoconductor offers superior performance over amorphous selenium (a-Se) for direct detection systems ID: D2014-09Invention Description and Novelty: Radiation detector device utilizes polycrystalline cadmium telluride (CdTe) thin films (less than 1 mm thick) with superior radiation hardness and better detection efficiency for both high energy (megaelectron volt--MeV) and low energy (kiloelectron volt--keV) range X-rays. Physical properties of CdTe include mechanical and chemical stability, high atomic number of 50, low ionization energy, large band gap and outstanding radiation hardness which make it a very attractive choice for these detection systems. Using easier to grow and typical...Wed, 26 Mar 2014 12:45:35 GMTsandy.rhoades@utoledo.edu System for Sensing Chlorine Gas, 26 Feb 2014 08:57:14 GMTsandy.rhoades@utoledo.edu Aptamer Functionalized SPR Sensor Project ID: D2012-07 IP Status: Provisional Application Invention novelty and description: This novel invention describes sensors for target entities having at least one amine-terminated aptamer specific to the target entity. Aptamers are artificial oligonucleotides which can serve as antibody mimics because of their high affinity and selectivity for various target compounds ranging from small molecules, such as drugs and dyes, to complex biological molecules such as enzymes, peptides, and proteins. Aptamers are also capable of being reversibly denatured for the release of target compounds...Fri, 24 Jan 2014 06:05:03 GMTsandy.rhoades@utoledo.edu Toxicology Screening Assay for Drug Molecules, 05 Dec 2013 13:07:06 GMTsandy.rhoades@utoledo.edu Assay to Screen Drug like Molecules for Antibiotic Activity, 05 Dec 2013 13:07:05 GMTsandy.rhoades@utoledo.edu Anti-Fouling Properties of Novel Composite Material Project ID: D2013-31 Novelty: Development of a novel electromagnetic polymer composite material for enhanced anti-fouling effects. Background: Biofouling (bacterial attachment to solid surfaces and colonization) is the main source of bacterial infection and poses potentially harmful impacts on human health. Medical devices, food packaging, and drinking water distribution systems are all susceptible to biofouling. For example, biofouling in an indwelling urinary tract catheter (IUTC) is the cause of 80% of urinary tract infections (UTI), the most common hospital associated infection. Controll...Fri, 04 Oct 2013 11:47:30 GMTsandy.rhoades@utoledo.edu Shock Protein 56 Monoclonal Antibody, 16 Sep 2013 07:14:15 GMTsandy.rhoades@utoledo.edu Silver Nanoparticles, 08 Jul 2013 12:57:49 GMTsandy.rhoades@utoledo.edu Method to Prepare Isoflavene and Chromane Analogs ID: D2011-60Novelty: A practical and novel intramolecular wittig reaction procedure for the production of variously substituted isoflavene and chromane analogs. Value proposition: Development of safe and economic manufacturing processes for natural product derivatives have always been a priority in the industry. Isoflavene systems require thallium mediated rearrangement step which is highly toxic to both the humans and to the environment. The researchers at The University of Toledo have developed a novel synthetic route, an intramolecular wittig reaction, to synthesize higher yields of...Mon, 03 Jun 2013 12:08:42 GMTsandy.rhoades@utoledo.edu Carcinoma Cell Line, 19 Dec 2012 10:33:00 GMTsandy.rhoades@utoledo.edu 1 (18D4) Monoclonal Antibody, 19 Dec 2012 10:24:39 GMTsandy.rhoades@utoledo.edu (6F9) Monoclonal Antibody, 19 Dec 2012 10:24:37 GMTsandy.rhoades@utoledo.edu sensitive portable technique for detecting wide variety of biological analytes, 20 Nov 2012 08:13:34 GMTsandy.rhoades@utoledo.edu Coli plasmid (pET32) encoding MTA/SAH nucleosidase, 24 Oct 2012 11:36:58 GMTsandy.rhoades@utoledo.edu and Purification of Human P-12-LOX, 24 Oct 2012 11:36:57 GMTsandy.rhoades@utoledo.edu labeling and B cell phenotyping of PPS specific B cells, 24 Oct 2012 11:36:56 GMTsandy.rhoades@utoledo.edu resonant self-heating battery circuit for use in hybrid and electric vehicles Project ID: ENG0098B Invention Description and Novelty: This technology includes an apparatus connected to an energy storage device for powering an electric motor and optionally providing a warming function for the energy storage device. The apparatus includes a circuit connected to the electric motor and the energy storage device for generating a current and a switching device associated with the circuit for selectively directing the current to one of the electric motor or the energy storage device. The circuit also includes a storage circuit with a resonating frequency for storing energy....Wed, 24 Oct 2012 11:36:54 GMTsandy.rhoades@utoledo.edu circuit for measuring series-connected electrochemical cell voltages for use in hybrid and electric vehicles Project ID: ENG0098C Invention Description and Novelty: An electronic circuit for efficiently and accurately measuring individual voltages in a series-connected electrochemical energy storage device which may be utilized with electric and hybrid vehicles. This technology includes a voltage transfer circuit for measuring the individual segment voltages within an energy storage device. The circuit includes a plurality of battery segments forming the energy storage device. An amplifier circuit is connected across one of the battery segments for converting a differential voltage to a reference ...Wed, 24 Oct 2012 11:36:53 GMTsandy.rhoades@utoledo.edu circuit for measuring series-connected electrochemical cell voltages and heating energy storage devices (batteries) for hybrid and electric vehicles Project ID: ENG0098A Invention Description and Novelty: A common requirement for large stacks of electrochemical cells used in electric and hybrid vehicles is the need to measure individual or groups of cell voltages almost simultaneously. The principal problem with current techniques of voltage measurement is that a small error in measuring the nodal voltages translates into a large relative error in the measurement of segment voltages. This technology provides an electronic circuit for measuring voltage signals in an energy storage device. The voltage level of each cell within the batter...Wed, 24 Oct 2012 11:36:52 GMTsandy.rhoades@utoledo.edu Electric Vehicle Energy Storage System, 24 Oct 2012 11:36:51 GMTsandy.rhoades@utoledo.edu Glucocorticoid Receptor beta Polyclonal Antibody, 23 Oct 2012 07:48:06 GMTsandy.rhoades@utoledo.edu Tuberculosis Drug Molecules Screening Assay, 23 Oct 2012 07:48:03 GMTsandy.rhoades@utoledo.edu (6A9) Monoclonal Antibody, 16 Oct 2012 11:56:38 GMTsandy.rhoades@utoledo.edu (12H6) Monoclonal Antibody, 16 Oct 2012 11:56:37 GMTsandy.rhoades@utoledo.edu (10B2) Monoclonal Antibody, 16 Oct 2012 11:56:33 GMTsandy.rhoades@utoledo.edu (Protocadherin 30) Monoclonal Antibody (8C5), 16 Oct 2012 11:56:32 GMTsandy.rhoades@utoledo.edu (8C11) Monoclonal Antibody, 16 Oct 2012 11:56:29 GMTsandy.rhoades@utoledo.edu (13A9) Monoclonal Antibody, 16 Oct 2012 11:56:28 GMTsandy.rhoades@utoledo.edu 2(6D8) Monoclonal Antibody, 16 Oct 2012 09:01:19 GMTsandy.rhoades@utoledo.edu 3 (5G11) Monoclonal Antibody, 16 Oct 2012 09:01:18 GMTsandy.rhoades@utoledo.edu (12F7) Monoclonal Antibody, 16 Oct 2012 09:01:17 GMTsandy.rhoades@utoledo.edu 3 (5H10) Monoclonal Antibody, 16 Oct 2012 09:01:16 GMTsandy.rhoades@utoledo.edu (11E4) Monoclonal Antibody, 16 Oct 2012 09:01:15 GMTsandy.rhoades@utoledo.edu (15B8) Monoclonal Antibody, 16 Oct 2012 09:01:15 GMTsandy.rhoades@utoledo.edu (9F2) Monoclonal Antibody, 16 Oct 2012 09:01:14 GMTsandy.rhoades@utoledo.edu (15F11) Monoclonal Antibody, 16 Oct 2012 09:01:11 GMTsandy.rhoades@utoledo.edu 2 (8E5) Monoclonal Antibody, 16 Oct 2012 09:01:11 GMTsandy.rhoades@utoledo.edu (7G6) Monoclonal Antibody, 16 Oct 2012 09:01:10 GMTsandy.rhoades@utoledo.edu 1 (27B2) Monoclonal Antibody, 16 Oct 2012 09:01:08 GMTsandy.rhoades@utoledo.edu (1G5) Monoclonal Antibody, 16 Oct 2012 05:55:15 GMTsandy.rhoades@utoledo.edu and method for predicting, preventing and/or treating autoimmune disorders including Type 1 diabetes, 28 Sep 2012 12:24:18 GMTsandy.rhoades@utoledo.edu Fluorescent Calcium Phosphate Nanowhiskers for Multifunctional Imaging Applications, 28 Sep 2012 11:36:14 GMTsandy.rhoades@utoledo.edu Epothilone Analogues as Antileukemia Agents and Method Thereof, 28 Sep 2012 11:36:13 GMTsandy.rhoades@utoledo.edu of Novel Calcium Phosphate Nanowhiskers, 28 Sep 2012 11:36:12 GMTsandy.rhoades@utoledo.edu Functional Two-Terminal Nanoelectronic Memristor Device, 28 Sep 2012 11:36:11 GMTsandy.rhoades@utoledo.edu Frame Rate Imaging System, 28 Sep 2012 11:36:10 GMTsandy.rhoades@utoledo.edu Pin Holes, Weak Shunts, and Scribe Lines of Photovoltaic Devices, 28 Sep 2012 09:30:03 GMTsandy.rhoades@utoledo.edu Synthesis of Difficult Peptides and Peptide Conjugates, 28 Sep 2012 09:30:01 GMTsandy.rhoades@utoledo.edu Shape Memory Alloy Pedicle Screw to Compensate for Bone Degradation, 28 Sep 2012 09:29:53 GMTsandy.rhoades@utoledo.edu temperature method for production of multiple biofuels and products from oleaginous biomass feedstocks, 28 Sep 2012 09:29:49 GMTsandy.rhoades@utoledo.edu Corpectomy Cage for Cervical Spine Reconstruction, 28 Sep 2012 09:29:40 GMTsandy.rhoades@utoledo.edu Gas Purification Catalysts and Methods of Making the Same, 28 Sep 2012 09:29:38 GMTsandy.rhoades@utoledo.edu Reactor System for use with Solid Oxide Fuel Cells, 28 Sep 2012 09:29:37 GMTsandy.rhoades@utoledo.edu Temperature Sulfur Sorbents, 28 Sep 2012 09:29:33 GMTsandy.rhoades@utoledo.edu Non-ATP Competitive SRC Inhibitor for Treating Cancer, 27 Sep 2012 07:55:51 GMTsandy.rhoades@utoledo.edu Protein Tames Bleeding In Haemophiliacs and Targets Angiogenesis in Cancer, 27 Sep 2012 07:40:52 GMTsandy.rhoades@utoledo.edu Class of Materials for Boron Extraction, 27 Sep 2012 07:40:51 GMTsandy.rhoades@utoledo.edu Peptides: Effective Therapeutics for Late Stage Prostate and Other EZH2-Dependent Cancers, 27 Sep 2012 07:40:49 GMTsandy.rhoades@utoledo.edu Inhibitors/Activators of Src and Src Family Kinases, 27 Sep 2012 07:40:47 GMTsandy.rhoades@utoledo.edu Peptide as Diagnostic and Therapeutic Tool for Cancer, 27 Sep 2012 06:37:40 GMTsandy.rhoades@utoledo.edu Epothilone Analogues as Antileukemia Agents and Method Thereof, 27 Sep 2012 06:37:38 GMTsandy.rhoades@utoledo.edu Peptide for Treatment of Benign Prostate Hyperplasia, 27 Sep 2012 05:32:01 GMTsandy.rhoades@utoledo.edu Bifunctional Catalyst and Methods for Synthesis of Optically Pure ß-Lactones, 25 Sep 2012 11:01:44 GMTsandy.rhoades@utoledo.edu