Latest technologies from The University of Toledohttp://utoledo.technologypublisher.comBe the first to know about the latest inventions and technologies available from The University of Toledoen-USFri, 20 Jul 2018 03:07:17 GMTTue, 29 May 2018 06:18:24 GMThttp://blogs.law.harvard.edu/tech/rsssandy.rhoades@utoledo.eduCopyright 2018, The University of Toledo1,3-Butanediol as a therapeutic for salt-sensitive hypertensionhttp://utoledo.technologypublisher.com/technology/27771Tue, 29 May 2018 06:18:24 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27771Altering shear thickening in fumed silica suspensions using nanoparticleshttp://utoledo.technologypublisher.com/technology/27764Thu, 24 May 2018 13:27:39 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27764Ocular Ultrasound Training Simulator (OUTS)http://utoledo.technologypublisher.com/technology/27641Wed, 02 May 2018 12:35:25 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27641Fixation and Reconstruction System for Ankle Fractureshttp://utoledo.technologypublisher.com/technology/27597Mon, 23 Apr 2018 12:58:09 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27597Novel Method for Reverse Automated Nucleic Acid Synthesishttp://utoledo.technologypublisher.com/technology/27596Mon, 23 Apr 2018 12:50:01 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27596External Locking Fixation for Tibia Fractureshttp://utoledo.technologypublisher.com/technology/27595Mon, 23 Apr 2018 10:42:46 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27595Tin whisker growth mitigation by using nickel oxide sublayershttp://utoledo.technologypublisher.com/technology/27572Tue, 17 Apr 2018 11:56:27 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27572Inexpensive, Earth-Abundant, and Tunable Hole Transport Material for CdTe Solar Cellshttp://utoledo.technologypublisher.com/technology/27551Mon, 16 Apr 2018 08:55:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27551 Iron Pyrite Nanocrystal Back Contact for CdTe Solar Cellshttp://utoledo.technologypublisher.com/technology/27550Mon, 16 Apr 2018 08:47:09 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27550Micropatterned Silicone Oxygenating Dressing For Chronic Woundshttp://utoledo.technologypublisher.com/technology/27514Mon, 09 Apr 2018 07:00:59 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27514Pyrrole-Based Composites for Metal Extraction and Analysishttp://utoledo.technologypublisher.com/technology/27416Mon, 26 Mar 2018 07:20:56 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27416Sensor and assay for screening of photosensitizers in living cellshttp://utoledo.technologypublisher.com/technology/27406Thu, 22 Mar 2018 09:36:04 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27406Pyrrole-Based Extraction Materials for Microcystin Separation and Analysishttp://utoledo.technologypublisher.com/technology/27359Wed, 14 Mar 2018 07:16:35 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27359High yield production of fuels and petro- or oleo-chemical precursors from vegetables oils/liquid feedstocks in a continuous-flow pyrolysis reactorhttp://utoledo.technologypublisher.com/technology/27299Tue, 13 Mar 2018 09:27:02 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27299 Two-step method for production of multiple biofuels and products from Non-Lignocellosic Biomasshttp://utoledo.technologypublisher.com/technology/27298Tue, 13 Mar 2018 08:58:46 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27298High Yield Algal Biomass Production Without Concentrated CO¬2 Supply Under Open Pond Conditionshttp://utoledo.technologypublisher.com/technology/27297Tue, 13 Mar 2018 08:53:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27297A Novel Process to Coat Implant Surfaces with Bi-Functional Bioactive Antibacterial Coatingshttp://utoledo.technologypublisher.com/technology/27237Mon, 05 Mar 2018 06:41:57 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27237Functionally graded graphene transient electronicshttp://utoledo.technologypublisher.com/technology/27062Mon, 05 Feb 2018 07:54:21 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27062Homogenous and Reusable Superacid Polymer Catalyst for the Synthesis of 5-Hydroxymethylfurfural from Glucosehttp://utoledo.technologypublisher.com/technology/26968Thu, 25 Jan 2018 08:18:36 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26968Carbon Dioxide as a Directing Group for C-H Functionalization Reactionshttp://utoledo.technologypublisher.com/technology/26944Tue, 23 Jan 2018 05:41:38 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/269443D Printable Bioactive Glass/Polymer Compositehttp://utoledo.technologypublisher.com/technology/26940Mon, 22 Jan 2018 12:28:04 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26940Novel Composite Sensor for Detecting Free Radicalshttp://utoledo.technologypublisher.com/technology/26898Wed, 17 Jan 2018 05:50:35 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26898Treatment of Ischemic Stroke with ROS-Sensitive Nitric Oxide Synthase Inhibitorshttp://utoledo.technologypublisher.com/technology/26897Wed, 17 Jan 2018 05:44:11 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26897Stiff Gel Adhesives for Underwater Usehttp://utoledo.technologypublisher.com/technology/26890Project ID: D2014-08Background Underwater adhesion has several potential medical, household and industrial applications. Generally, underwater adhesives have been prepared using methods that rely on in situ polymerization, covalent crosslinking, or the use of highly specialized biological or biomimetic polymers. Despite current strategies, many challenges have limited the yield and application of biomimetic adhesives including cost, inefficient recombinant protein production, complicated syntheses, the use of potentially harmful oxidants and the need for highly specialized polymer structures. ...Tue, 16 Jan 2018 12:56:18 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26890Enhanced Immunogenicity Vaccine Development Platformhttp://utoledo.technologypublisher.com/technology/26847Wed, 10 Jan 2018 09:18:40 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26847Ventilator-Associated Events (VAE) Clinical Risk Calculatorhttp://utoledo.technologypublisher.com/technology/26845Wed, 10 Jan 2018 08:14:50 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26845One Step Liquid To Metal High Surface Area Platinum Catalyst Via Low Temperature Reductionhttp://utoledo.technologypublisher.com/technology/26775Tue, 19 Dec 2017 10:57:56 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26775A new class of HDAC inhibitors with a new metal-binding grouphttp://utoledo.technologypublisher.com/technology/26737Mon, 18 Dec 2017 05:51:48 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26737Synthesis of Novel Calcium Phosphate Nanowhiskershttp://utoledo.technologypublisher.com/technology/26639Wed, 29 Nov 2017 11:20:52 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26639Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogenshttp://utoledo.technologypublisher.com/technology/26637Wed, 29 Nov 2017 10:55:28 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26637Ultrastable Silver Nanoparticleshttp://utoledo.technologypublisher.com/technology/26613Wed, 22 Nov 2017 10:39:58 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26613Immunostimulatory adjuvant molecules and antibody recruiting molecule-containing lipopeptide vaccineshttp://utoledo.technologypublisher.com/technology/26349Mon, 02 Oct 2017 08:10:45 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26349Concurrent Delivery of Interstitial Thermobrachytherapy in Cancer Treatmenthttp://utoledo.technologypublisher.com/technology/26348Mon, 02 Oct 2017 07:53:41 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26348Muscarinic Agonists for the Treatment of Autism Spectrum Disorderhttp://utoledo.technologypublisher.com/technology/26027Mon, 14 Aug 2017 05:51:19 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26027Furoxans as Novel Therapeutics for Neurodegenerative Disordershttp://utoledo.technologypublisher.com/technology/24538Mon, 06 Mar 2017 09:36:24 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/24538Use of Small Molecule Inhibitors as Anti-Thrombotic Agentshttp://utoledo.technologypublisher.com/technology/23722Project: D2016-03IP Status: PCT filed Invention Description: Discovery of a new family of small molecules that can be used to decrease the risk of thrombosis in patients with several diseases. Novelty: The most important aspect of this new antithrombotic is that it prevents the transition of platelets to a hypersensitive state without impacting normal hemostatic responses. Current therapies target major platelet activation pathways while our molecule targets a specific pathway only involved in hypersensitivity but not in coagulation. Treating patients with conditions such as systemic lupus ery...Wed, 21 Dec 2016 09:26:18 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/23722 Cost- and Energy-Efficient Device for De-watering Microalgae Using Stimuli-Sensitive Hydrogelshttp://utoledo.technologypublisher.com/technology/23721Wed, 21 Dec 2016 09:17:50 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/23721Topical Treatment for Raynaud’s Phenomenon Targets Cold Receptorhttp://utoledo.technologypublisher.com/technology/23505Wed, 09 Nov 2016 07:45:01 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/23505Anti-Beta-Catenin (5H10) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/22983Mon, 10 Oct 2016 07:23:02 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22983 Immuno-oncology--Tn-specific monoclonal IgM antibody binds and kills human tumor cellshttp://utoledo.technologypublisher.com/technology/22880Wed, 21 Sep 2016 10:24:31 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22880Anti-properdin monoclonal antibody 1G6D2http://utoledo.technologypublisher.com/technology/22763Tue, 30 Aug 2016 06:27:14 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22763Anti-properdin monoclonal antibody 3A3E1http://utoledo.technologypublisher.com/technology/22762Tue, 30 Aug 2016 06:22:23 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22762Anti-properdin monoclonal antibody 6E11A4http://utoledo.technologypublisher.com/technology/22761Tue, 30 Aug 2016 06:19:47 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22761New Species-Selective Antimicrobials to Thwart Developing Resistancehttp://utoledo.technologypublisher.com/technology/22434Project ID: D2015-58IP Status: PCT patent application filedInvention Description and Novelty: Drug resistance limits the effectiveness of most currently used antimicrobial agents. Infectious organisms are becoming resistant to even the most recently developed antimicrobials that target essential steps in cell wall assembly and protein biosynthesis. Researchers at The University of Toledo have created new antimicrobials with unique modes of action against a new drug target.Applications: Compounds and methods for developing new antimicrobials that are species-selective and act through a mechanis...Wed, 13 Jul 2016 06:36:28 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22434Anti-Infective Antibacterial Agents against Mycobacterium Tuberculosis and other Mycobacterium Specieshttp://utoledo.technologypublisher.com/technology/22402Wed, 06 Jul 2016 11:40:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22402Method to Develop Compounds for Treating Canavan Diseasehttp://utoledo.technologypublisher.com/technology/22397Tue, 05 Jul 2016 12:58:29 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22397“Thin” Molecules for Treating Obesity and Type II Diabeteshttp://utoledo.technologypublisher.com/technology/21699Thu, 07 Apr 2016 08:57:10 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21699Loading Platform for Three-Dimensional Tissue Engineering Scaffoldshttp://utoledo.technologypublisher.com/technology/21692Wed, 06 Apr 2016 12:50:02 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21692“Sweet-P”: Molecule for Targeting Human Glucocorticoid Receptor Beta in Cancerhttp://utoledo.technologypublisher.com/technology/21691Wed, 06 Apr 2016 12:34:39 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21691Process to Produce High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Implants and Hardwarehttp://utoledo.technologypublisher.com/technology/21394Wed, 10 Feb 2016 13:01:21 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21394A Bi-level Equalizer for Battery Cell Charge Managementhttp://utoledo.technologypublisher.com/technology/21393Wed, 10 Feb 2016 12:40:29 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21393Unique family of trianionic ligand precursors provide unprecedented control over polymer propertieshttp://utoledo.technologypublisher.com/technology/21013Wed, 02 Dec 2015 07:12:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21013Biomimetic approach to deposit bone-like coating on PEEK and other materials to improve osteoconductivity in implantshttp://utoledo.technologypublisher.com/technology/21012Project ID: D2011-33IP Status: Patent Pending U.S and EuropeInvention Description: Novel method to prepare an implantable article comprised of a biocompatible substrate (polymeric or ceramic) to accept a very thin biocompatible, bioactive coating material to facilitate bio-ingrowth between the substrate and bone or cartilage tissue.Applications: Bone fractures treated with wires, nails, screws, and plates; joints replaced by artificial endoprostheses; dental implants; other.Novelty: Uses microwave energy to form a carbonated calcium deficient hydroxyapatite (CDHA) layer on the surface of impla...Wed, 02 Dec 2015 07:09:33 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21012Generation of Stable iTregs as Therapeutics against Autoimmune Diseases (Type I Diabetes)http://utoledo.technologypublisher.com/technology/19902Mon, 06 Jul 2015 11:53:54 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19902Ring-Closing Metathesis Creates Nylon-11, -12 and -13 Precursors from Widely Abundant Plant-Derived Biomasshttp://utoledo.technologypublisher.com/technology/19806 Project ID: D2014-39 IP Status: Provisional patent #62/020,488 filed Invention Description: Invention relates to a new ring-closing-metathesis approach for making C11, C12 and C13 lactams (cyclic form of amino acids) from oleic acid or alkyl esters originating from lipids. The method allows direct conversion of the widely abundant natural fatty acid oleic acid into synthetic precursors of nylon-11, -12 and -13 in fewer steps than previously developed methods. Applications: Applications include automotive, transportation, sports, medical, high-performance cables, electronics, electrical compo...Thu, 18 Jun 2015 12:52:30 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19806Methods for Production of Fatty Acid Alkanolamides (FAAAs) from Microalgae Biomasshttp://utoledo.technologypublisher.com/technology/19805Thu, 18 Jun 2015 12:52:29 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19805Renewable Alternatives to Petroleum-Derived Products: Novel Approach Creates Nylon-12 and -13 Precursors from Lipidshttp://utoledo.technologypublisher.com/technology/19804 Project ID: D2014-06 Invention Description: Invention relates to a new olefin cross-metathesis approach for making C12 and C13 amino esters from oleic acid (or alkyl esters) originating from lipids. The method allows direct conversion of the widely abundant natural fatty acid oleic acid into synthetic precursors or nylon-12 and nylon-13 in half the steps than previously developed methods. Applications: Applications include automotive, transportation, sports, medical, high-performance cables, electronics, electrical compounds, photovoltaic panels, and even lenses for glasses. Novelty: Effic...Thu, 18 Jun 2015 12:52:28 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19804Use of fluorescent ANTS to examine the BBB-permeability of polysaccharidehttp://utoledo.technologypublisher.com/technology/19797Wed, 17 Jun 2015 11:37:27 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19797Novel agents and methods for treating neurodegenerative disordershttp://utoledo.technologypublisher.com/technology/19796Wed, 17 Jun 2015 11:37:25 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19796Novel agents and methods for treating metabolic bone disorders and other conditionshttp://utoledo.technologypublisher.com/technology/19794Wed, 17 Jun 2015 11:06:24 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19794E-Cadherin (4A2) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/19703Tue, 02 Jun 2015 12:20:03 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19703Novel HDAC Inhibitors as Anti-Cancer Agentshttp://utoledo.technologypublisher.com/technology/19418Thu, 14 May 2015 12:02:34 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19418Diagnostic Laryngeal Mechanosensor Stimulatorhttp://utoledo.technologypublisher.com/technology/18229Thu, 05 Feb 2015 10:20:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/18229Small Drug-Like Molecules as Anticancer Agents Selective for Cancer Stem Cellshttp://utoledo.technologypublisher.com/technology/18210Project ID: D2013-04Novelty: A new class of anticancer agents which are highly selective for mesenchymal cancer cells with stem cell like properties.Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the same time, tumors are heterogeneous and current evidence suggests that a subpopulation of tumor cells, called tumor initiating or cancer stem cells are responsible for metastatic dissemination, tumor relapse and possibly drug resistance. Classical apoptotic drugs are less effective against this...Tue, 03 Feb 2015 10:22:31 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/18210Advancement in Platinum Based Cancer Therapeuticshttp://utoledo.technologypublisher.com/technology/15747Project ID: D2014-33Novelty: Small drug like molecules that inhibits DNA repair factors for cisplatin (and other platinum based drugs) resistance towards solid tumors, thereby increasing cisplatin cytotoxicity and efficacy. Value proposition: One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer cells. Although increased DNA repair has been shown to be a major mechanism of cancer drug resistance, not much was done until recently to address this challenge. The researchers at The University of Toledo have discovered small drug like molecules th...Tue, 19 Aug 2014 08:26:50 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15747Biodegradable Magnesium/Rare Earth Alloys for Biomedical Implantshttp://utoledo.technologypublisher.com/technology/15628Mon, 28 Jul 2014 08:19:00 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15628Injectable Biodegradable Bone Matrix for Multiple Myeloma Lesion Augmentation and Osteoporosishttp://utoledo.technologypublisher.com/technology/15627Mon, 28 Jul 2014 08:09:30 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15627Minimally-Invasive Spinal Deformity Correction Device for Children and Adolescentshttp://utoledo.technologypublisher.com/technology/15558 Project ID: D2009-90 Invention Description: Patented technology combines a hybrid rod-cable that loops around rotatory pedicle screws anchored to the proximal-most vertebrae within the spinal deformity to correct scoliosis. The device may be placed in any region of the spine, but is typically located in the thoracic or lumbar regions. Growth and elongation of the spinal column on the convex side of the curve is exploited to correct growth inequality between the two sides. The construct has four different components--fixed, intermediate, and rotatory anchors plus a unitized cable for anchorin...Mon, 21 Jul 2014 06:33:16 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15558Stabilized Spinal Fixation Hookhttp://utoledo.technologypublisher.com/technology/15529Tue, 15 Jul 2014 12:38:28 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15529Anchoring pedicle screwhttp://utoledo.technologypublisher.com/technology/15527Tue, 15 Jul 2014 12:31:20 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15527Lateral Fixation Assembly for Spinal Columnhttp://utoledo.technologypublisher.com/technology/15521Tue, 15 Jul 2014 06:26:18 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15521Novel Pedicle Screw Assembly for Minimally Invasive Surgeryhttp://utoledo.technologypublisher.com/technology/15520Mon, 14 Jul 2014 13:23:25 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15520Small Molecule to Modulate Skin Pigmentationhttp://utoledo.technologypublisher.com/technology/15239Wed, 21 May 2014 08:02:05 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15239Humanized Endothelial Specific TRPC3 Transgenic Mousehttp://utoledo.technologypublisher.com/technology/14995 Project: D2012-18 Strains: EST3Tg/C57BL6 and EST3Tg/Apoe-/- Type: Humanized transgenic mouse Background: In the U.S., atherosclerosis, hypertension and stroke are the major causes of death due to cardiovascular disease and remain most frequent vascular complications of metabolic diseases such as diabetes, obesity and metabolic syndrome. A common signature of the associated vascular pathology is the presence of a dysfunctional endothelium, endothelial inflammation and/or changes in endothelial integrity. Research over the last fifteen years led to identification of members of the Transient Re...Mon, 07 Apr 2014 12:36:21 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14995Novel Fluorescent Probe and Assay for Quantifying Adenosine and Adenosyl-Containing Compounds in Solutionhttp://utoledo.technologypublisher.com/technology/14990Fri, 04 Apr 2014 12:46:52 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14990No-Heat-Required System for Sensing Chlorine Gashttp://utoledo.technologypublisher.com/technology/14588Wed, 26 Feb 2014 08:57:14 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14588Amine-terminated Aptamer Functionalized SPR Sensorhttp://utoledo.technologypublisher.com/technology/14325 Project ID: D2012-07 IP Status: Provisional Application Invention novelty and description: This novel invention describes sensors for target entities having at least one amine-terminated aptamer specific to the target entity. Aptamers are artificial oligonucleotides which can serve as antibody mimics because of their high affinity and selectivity for various target compounds ranging from small molecules, such as drugs and dyes, to complex biological molecules such as enzymes, peptides, and proteins. Aptamers are also capable of being reversibly denatured for the release of target compounds...Fri, 24 Jan 2014 06:05:03 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14325Novel Toxicology Screening Assay for Drug Moleculeshttp://utoledo.technologypublisher.com/technology/14025Thu, 05 Dec 2013 13:07:06 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14025Novel Assay to Screen Drug like Molecules for Antibiotic Activityhttp://utoledo.technologypublisher.com/technology/14024Thu, 05 Dec 2013 13:07:05 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14024Enhanced Anti-Fouling Properties of Novel Composite Materialhttp://utoledo.technologypublisher.com/technology/13478 Project ID: D2013-31 Novelty: Development of a novel electromagnetic polymer composite material for enhanced anti-fouling effects. Background: Biofouling (bacterial attachment to solid surfaces and colonization) is the main source of bacterial infection and poses potentially harmful impacts on human health. Medical devices, food packaging, and drinking water distribution systems are all susceptible to biofouling. For example, biofouling in an indwelling urinary tract catheter (IUTC) is the cause of 80% of urinary tract infections (UTI), the most common hospital associated infection. Controll...Fri, 04 Oct 2013 11:47:30 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/13478Heat Shock Protein 56 Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/13397Mon, 16 Sep 2013 07:14:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/13397Novel Method to Prepare Isoflavene and Chromane Analogshttp://utoledo.technologypublisher.com/technology/12669Project ID: D2011-60Novelty: A practical and novel intramolecular wittig reaction procedure for the production of variously substituted isoflavene and chromane analogs. Value proposition: Development of safe and economic manufacturing processes for natural product derivatives have always been a priority in the industry. Isoflavene systems require thallium mediated rearrangement step which is highly toxic to both the humans and to the environment. The researchers at The University of Toledo have developed a novel synthetic route, an intramolecular wittig reaction, to synthesize higher yields of...Mon, 03 Jun 2013 12:08:42 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/12669A431D Carcinoma Cell Linehttp://utoledo.technologypublisher.com/technology/11663Wed, 19 Dec 2012 10:33:00 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11663Desmoglein 1 (18D4) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11662Wed, 19 Dec 2012 10:24:39 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11662Anti-Beta-Catenin (6F9) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11661Wed, 19 Dec 2012 10:24:37 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11661Highly sensitive portable technique for detecting wide variety of biological analyteshttp://utoledo.technologypublisher.com/technology/11477Tue, 20 Nov 2012 08:13:34 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11477E. Coli plasmid (pET32) encoding MTA/SAH nucleosidasehttp://utoledo.technologypublisher.com/technology/11376Wed, 24 Oct 2012 11:36:58 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11376Fluorescent labeling and B cell phenotyping of PPS specific B cellshttp://utoledo.technologypublisher.com/technology/11374Wed, 24 Oct 2012 11:36:56 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11374Efficient resonant self-heating battery circuit for use in hybrid and electric vehicleshttp://utoledo.technologypublisher.com/technology/11372 Project ID: ENG0098B Invention Description and Novelty: This technology includes an apparatus connected to an energy storage device for powering an electric motor and optionally providing a warming function for the energy storage device. The apparatus includes a circuit connected to the electric motor and the energy storage device for generating a current and a switching device associated with the circuit for selectively directing the current to one of the electric motor or the energy storage device. The circuit also includes a storage circuit with a resonating frequency for storing energy....Wed, 24 Oct 2012 11:36:54 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11372Electronic circuit for measuring series-connected electrochemical cell voltages for use in hybrid and electric vehicleshttp://utoledo.technologypublisher.com/technology/11371 Project ID: ENG0098C Invention Description and Novelty: An electronic circuit for efficiently and accurately measuring individual voltages in a series-connected electrochemical energy storage device which may be utilized with electric and hybrid vehicles. This technology includes a voltage transfer circuit for measuring the individual segment voltages within an energy storage device. The circuit includes a plurality of battery segments forming the energy storage device. An amplifier circuit is connected across one of the battery segments for converting a differential voltage to a reference ...Wed, 24 Oct 2012 11:36:53 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11371Electronic circuit for measuring series-connected electrochemical cell voltages and heating energy storage devices (batteries) for hybrid and electric vehicleshttp://utoledo.technologypublisher.com/technology/11370 Project ID: ENG0098A Invention Description and Novelty: A common requirement for large stacks of electrochemical cells used in electric and hybrid vehicles is the need to measure individual or groups of cell voltages almost simultaneously. The principal problem with current techniques of voltage measurement is that a small error in measuring the nodal voltages translates into a large relative error in the measurement of segment voltages. This technology provides an electronic circuit for measuring voltage signals in an energy storage device. The voltage level of each cell within the batter...Wed, 24 Oct 2012 11:36:52 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11370Hybrid Electric Vehicle Energy Storage Systemhttp://utoledo.technologypublisher.com/technology/11369Wed, 24 Oct 2012 11:36:51 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11369M. Tuberculosis Drug Molecules Screening Assayhttp://utoledo.technologypublisher.com/technology/11365Tue, 23 Oct 2012 07:48:03 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11365P-Cadherin (6A9) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11345Tue, 16 Oct 2012 11:56:38 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11345P-Cadherin (12H6) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11344Tue, 16 Oct 2012 11:56:37 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11344Plakophilin-1 (10B2) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11343Tue, 16 Oct 2012 11:56:33 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11343FAT2 (Protocadherin 30) Monoclonal Antibody (8C5)http://utoledo.technologypublisher.com/technology/11342Tue, 16 Oct 2012 11:56:32 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11342N-Cadherin (8C11) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11341Tue, 16 Oct 2012 11:56:29 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11341N-Cadherin (13A9) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11340Tue, 16 Oct 2012 11:56:28 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11340Desmoglein 2(6D8) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11336Tue, 16 Oct 2012 09:01:19 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11336Desmoglein 3 (5G11) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11335Tue, 16 Oct 2012 09:01:18 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11335Anti-Beta-Catenin (12F7) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11333Tue, 16 Oct 2012 09:01:17 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11333Desmoglein 3 (5H10) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11332Tue, 16 Oct 2012 09:01:16 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11332Anti-Gamma-Catenin (11E4) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11331Tue, 16 Oct 2012 09:01:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11331Anti-Beta-Catenin (15B8) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11330Tue, 16 Oct 2012 09:01:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11330Anti-Beta-Catenin (9F2) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11329Tue, 16 Oct 2012 09:01:14 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11329Anti-Gamma-Catenin (15F11) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11327Tue, 16 Oct 2012 09:01:11 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11327Desmoglein 2 (8E5) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11326Tue, 16 Oct 2012 09:01:11 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11326Desmocollin (7G6) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11325Tue, 16 Oct 2012 09:01:10 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11325Desmoglein 1 (27B2) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11323Tue, 16 Oct 2012 09:01:08 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11323Anti-Alpha-Catenin (1G5) Monoclonal Antibodyhttp://utoledo.technologypublisher.com/technology/11319Tue, 16 Oct 2012 05:55:15 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11319Novel Epothilone Analogues as Antileukemia Agents and Method Thereofhttp://utoledo.technologypublisher.com/technology/11235Fri, 28 Sep 2012 11:36:13 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11235Uniquely Functional Two-Terminal Nanoelectronic Memristor Devicehttp://utoledo.technologypublisher.com/technology/11233Fri, 28 Sep 2012 11:36:11 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11233High Frame Rate Imaging Systemhttp://utoledo.technologypublisher.com/technology/11232Fri, 28 Sep 2012 11:36:10 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11232Filling Pin Holes, Weak Shunts, and Scribe Lines of Photovoltaic Deviceshttp://utoledo.technologypublisher.com/technology/11223Fri, 28 Sep 2012 09:30:03 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11223Solid-phase Synthesis of Difficult Peptides and Peptide Conjugateshttp://utoledo.technologypublisher.com/technology/11222Fri, 28 Sep 2012 09:30:01 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11222Bio-inspired Shape Memory Alloy Pedicle Screw to Compensate for Bone Degradationhttp://utoledo.technologypublisher.com/technology/11217Fri, 28 Sep 2012 09:29:53 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11217Expandable Corpectomy Cage for Cervical Spine Reconstructionhttp://utoledo.technologypublisher.com/technology/11211Fri, 28 Sep 2012 09:29:40 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11211Exhaust Gas Purification Catalysts and Methods of Making the Samehttp://utoledo.technologypublisher.com/technology/11210Fri, 28 Sep 2012 09:29:38 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11210Desulfurizer-Reformer Reactor System for use with Solid Oxide Fuel Cellshttp://utoledo.technologypublisher.com/technology/11209Fri, 28 Sep 2012 09:29:37 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11209High Temperature Sulfur Sorbentshttp://utoledo.technologypublisher.com/technology/11206Fri, 28 Sep 2012 09:29:33 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11206Novel Non-ATP Competitive SRC Inhibitor for Treating Cancerhttp://utoledo.technologypublisher.com/technology/11198Thu, 27 Sep 2012 07:55:51 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11198Engineered Protein Tames Bleeding In Haemophiliacs and Targets Angiogenesis in Cancerhttp://utoledo.technologypublisher.com/technology/11196Thu, 27 Sep 2012 07:40:52 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11196Novel Class of Materials for Boron Extractionhttp://utoledo.technologypublisher.com/technology/11195Thu, 27 Sep 2012 07:40:51 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11195Novel Peptides: Effective Therapeutics for Late Stage Prostate and Other EZH2-Dependent Cancershttp://utoledo.technologypublisher.com/technology/11194Thu, 27 Sep 2012 07:40:49 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11194Peptide Inhibitors/Activators of Src and Src Family Kinaseshttp://utoledo.technologypublisher.com/technology/11192Thu, 27 Sep 2012 07:40:47 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11192Novel Peptide for Treatment of Benign Prostate Hyperplasiahttp://utoledo.technologypublisher.com/technology/11185Thu, 27 Sep 2012 05:32:01 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11185Novel Bifunctional Catalyst and Methods for Synthesis of Optically Pure ß-Lactoneshttp://utoledo.technologypublisher.com/technology/11135Tue, 25 Sep 2012 11:01:44 GMTsandy.rhoades@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11135