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Improved resuscitation in hemorrhagic shock using polyethelyne glycol modified albumin (PEG-Alb).

Background Capillary leakage of important ions and proteins, such as albumin from blood vessels can lead to a buildup of fluid in interstitial space (organ swelling) as well as hypoperfusion of organs. Capillary leak (CL) is a central component of multiorgan failure and a secondary component to severe sepsis caused by bacterial or viral infections,...

SPME Device for Determining the Partition Coefficient of Xenobiotics into Marine Biomass

Project ID: TECH2023-34 Background Several studies have been conducted over the last few decades on the physical properties and chemical composition of the sea-surface microlayer as well as its chemical exchange processes at the air/sea interface. As a result of these studies, it has been demonstrated that a wide variety of xenobiotics are accumulated...

Species-specific inhibitors of methionine adenosyltransferase (MAT)

Project ID: TECH2023-31 Background Drug resistance, especially to antibiotics and other antimicrobials, is a huge and growing problem. Some bacteria already have untreatable strains, and other microbes have never had good drug options. Broad-spectrum antibiotics have substantial side effects, including microbiome disruption. Cryptosporidium parvum...

Minimally-Invasive Spinal Deformity Correction Device for Children and Adolescents

Project ID: D2009-90 Invention Description Patented technology combines a hybrid rod-cable that loops around rotatory pedicle screws anchored to the proximal-most vertebrae within the spinal deformity to correct scoliosis. The device may be placed in any region of the spine, but is typically located in the thoracic or lumbar regions. Growth and elongation...

Theory and Applications of Super-Resolution Imaging with Modulation of Point Spread Function

Project ID: TECH2024-09 Background High image resolution is a desired outcome in wave-related disciplines such as ultrasound, acoustics, optics, and electromagnetics. However, the spatial resolution of an imaging system is fundamentally limited by the spatial frequency of the point spread function (PSF) of the system due to diffraction. There have...

Smart Exosomes Enable Active Pdac Targeting and Evading Mononuclear Phagocycotic System

Project ID: D2021-13 Background: Patients affected by pancreatic ductal adenocarcinoma (PDAC), an aggressive type of cancer, have a 5-year survival rate of 9%, the lowest of any cancer in the US. Therapies for pancreatic cancer are largely hindered by the lack of an effective delivery system. Exosomes are emerging as promising nanocarriers for genes...

Modular Hip Distractor

Project ID: TECH-2023-10 Background Hip arthroscopy is a minimally invasive surgical technique involving the insertion of specialized instruments through small incisions into the hip joint. This approach is commonly employed to address various hip-related issues including femoroacetabular impingement (FAI), labral tears, and the extraction of loose...

Toward Wet Wipes that Turn into Toilet Paper when Flushed

Project ID: TECH-2023-20 Background Wet wipes have been shown to clog pipes and pumps in wastewater collection and treatment systems. Additionally, wet wipes contain microplastics that contribute to water pollution. Some governments are proposing restrictions or complete bans on wet wipe products. Therefore, there is a need for a truly flushable...

Combo Cup

Project ID: TECH-2023-28 Background Pelvic organ prolapse (POP) occurs when a pelvic organ slips from the normal position and down into the rectum or vagina. Patients can alleviate symptoms by inserting a pessary into the vagina to hold an organ in its normal position. This can be a great alternative to risky surgeries but is challenging or impossible...

Non-invasive Ocular Glucose Sensing

Project ID: D2010-12 Background Diabetes mellitus is a disease in which an individual has difficulty regulating their blood glucose levels, in which extremely low or high glucose concentrations can occur. Normal physiological blood glucose ranges are generally between 80-120 mg/dL; however, diabetics commonly have blood concentrations from 50-500...

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