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G-Tube Blockage Blaster
Tech ID: D2021-37 Background Gastronomy Tubes (G-Tube) are surgically implanted medical devices that create an access point to a patient’s stomach through a tube. Patients who have difficulty swallowing need G-tubes to get proper nutrition, hydration, and medications. Conditions, such as dementia, head injury, and cancer may cause swallowing...
Emulsion Formation using corona discharge and electrohydrodynamic pumping
Project ID: D2020-22 Background Making water-in-oil emulsions often requires high pressure, ultrasonication, or sensitive inversion techniques that may still only result in a semi-stable colloid. In addition to emulsion shelf life, these techniques have drawbacks, such as having high-energy consumption and narrow/sensitive production parameters, needing...
Fluorescent labeling and B cell phenotyping of PPS specific B cells
Project ID: D2011-08 Description: The phenotype of B cells responsible for the production of anti-pneumococcal polysaccharide antibody has been unclear. Although individuals that respond poorly to the 23-valent pneumococcal polysaccharide (PPS) vaccine, Pneumovax, are profoundly deficient or lack IgM memory cells (CD27+IgM+), they are also deficient...
Rapid Nuclear Receptor Fluorescence-Based Competitive Binding Assay
Project ID: 2019-47Background:Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that have become significant targets for addressing various metabolic disorders, including lipid dystrophies and diabetes. PPARs are nutrient receptors that have different selective and promiscuous ligands, including fatty acids and eicosanoids....
Novel Surgical Instrument Sleeve System
Project ID: D2019-29Background:Surgical instruments are designed to perform various surgical procedures and sutures are used to close the edges of incision or wounds or to repair damage tissues. During certain surgical procedures, often surgeons uses forceps to manipulate tissue and to align the tissue for passage of the needle. However, due to the...
Magnetic Ionic Liquids Based Extraction and Purification of Nucleic Acids
Project ID # D2014-41Background:With a market of $3 billion in 2018 growing at a CAGR of 9.6 %, the nucleic acid isolation and extraction is one of the complex achievements in modern science. The analysis of deoxyribonucleic acid (DNA) plays a central role in a variety of applications such as determining microbial diversity in environmental samples,...
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model of...
Methods for detecting exposure to cyantoxins
Project ID: D2018-46Background Harmful Algal Blooms (HAB) are becoming more frequent worldwide due to factors such as temperature increase and pollution. Microcystins (MC) are carcinogenic toxins released by the algae during a blooms. MC exposure can occur via skin contact, inhalation, and ingestion and can cause illness in people and animals. MC detection...
Ocular Ultrasound Training Simulator (OUTS)
Project ID: D2018-28Background The use of ocular ultrasound on emergency patients has recently been adopted by emergency physicians to evaluate for ocular pathology and emergencies. Point of care ultrasound (POCUS) has been found to be highly accurate in diagnosing and evaluating for ocular pathology in patients presenting in emergency departments....
Novel Method for Reverse Automated Nucleic Acid Synthesis
Project ID: D2017-49 Background Automated processes are widely used in the synthesis of modified oligonucleotide strands. These modified oligonucleotides are useful in the treatment or investigation of various conditions and diseases. Currently, the most common subunits used to synthesize RNA strands in the 3 to 5 direction are 3 phosphoramidites....
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