Search Results - Diagnostics

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Diagnosis of infertility caused by sperm centriole dysfunction
Project ID D2020-37 Background Couples struggling with infertility have the option of trying to expand their families with assisted reproductive technology (ART), such as in vitro fertilization. However, ART comes at a high cost and is only successful in about half of cases in the United States. Prior to electing ART, a couple’s fertility is...
Stratifying the risk of malignancy in indeterminate thyroid nodules
Project ID D2019-45 Background Thyroid cancer is the most common endocrine cancer globally, and accounts for 3.4% of all new cancer cases in the US. Although several clinical guidelines to detect/manage thyroid nodules are available, a great deal of controversy still exists around the optimal approach for diagnosis. Approximately 20-30% of cytology...
Super Sensitive Sensor For The Detection Of Hydroxyl Free Radicals in Food
Project ID: D2020-04 Background: Detection of free radicals (ROS) is vital in maintaining food safety as the estimated economic damage caused by the impact on food safety is $7 billion per year in the US. The presence of ROS causes devastating effects on the food as it leads to oxidation of proteins, breakage of oligonucleotides, or irreparable altering...
Super Sensitive Sensor for the Detection of Hydroxyl Free Radicals
Project ID: D2020-04 Reactive oxygen species (ROS) are well known for their extreme reactivity. The impact of free radicals on medical and clinical fields is critical as hydroxyl radicals (OH) can be used as biomarkers for the detection of aging, cancer, Alzheimer’s, and Parkinson’s diseases. Because certain types of free radicals are known...
Telestroke Eye Examination Device
Project ID: D2019-08 Background: With the unprecedented Covid19 outbreak, Telehealth's need is more than ever, and the expected Telehealth market is at $72 billion by 2027. With the rise of 5G network technology, doctors are now able to perform telesurgery uninterrupted and seamless. Currently, ischemic stroke is the leading cause of adult...
Diagnostic and therapeutic biomarkers in human cancers
Project ID D2020-01Background IQGAP is a regulatory scaffold protein that organizes actin and microtubule cytoskeleton to regulate cell movement, division, and adhesion. It is an oncoprotein that can transduce signals emanating from surface receptors to the nucleus to control gene expression. IQGAP1 protein is regulated by addition or removal of phosphate...
Methods for detecting exposure to cyantoxins
Project ID: D2018-46Background Harmful Algal Blooms (HAB) are becoming more frequent worldwide due to factors such as temperature increase and pollution. Microcystins (MC) are carcinogenic toxins released by the algae during a blooms. MC exposure can occur via skin contact, inhalation, and ingestion and can cause illness in people and animals. MC detection...