Search Results - Diagnostics

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Project ID: D2010-12 Background Diabetes mellitus is a disease in which an individual has difficulty regulating their blood glucose levels, in which extremely low or high glucose concentrations can occur. Normal physiological blood glucose ranges are generally between 80-120 mg/dL; however, diabetics commonly have blood concentrations from 50-500...

Rapid Screening For Elevated Bile Acids Using Whole Blood

Project ID: D2022-12 Background Chronic liver disease (CLD) exerts a huge economic burden causing 3.5% of deaths worldwide mainly due to poor early diagnosis of the disease. COVID-19 has also contributed a moderate impact causing further burden to CLD diagnosis. Cholemia and cholestasis are pathological conditions related to liver disorders with...

Compounds for non-lethal micropinocytosis and exosome production

Project ID: D2017-25 Background Exosomes are vesicles in the range of 30 to 120nm, which are released from mammalian cells when multi-vesicular endosomes fuse with the plasma membrane. In recent times, exosomes have been implicated in cancer. Mounting evidence suggests that exosomes play an important role in mediating intercellular communication...

Artificial Intelligence Based Platform for Medical Training, Skill Optimization, and Drug Use Prevention

Tech Id: D2020-06 Background: Currently, training or education across multiple domains and professions is completed using a “one size fits all” curriculum, where there is no dynamic personalization for a given learner. Instead, mission critical professions such as healthcare, emergency first responders, and the military often use pass/fail...

Diagnosis of infertility caused by sperm centriole dysfunction

Project ID D2020-37 Background Couples struggling with infertility have the option of trying to expand their families with assisted reproductive technology (ART), such as in vitro fertilization. However, ART comes at a high cost and is only successful in about half of cases in the United States. Prior to electing ART, a couple’s fertility is...

Stratifying the risk of malignancy in indeterminate thyroid nodules

Project ID D2019-45 Background Thyroid cancer is the most common endocrine cancer globally, and accounts for 3.4% of all new cancer cases in the US. Although several clinical guidelines to detect/manage thyroid nodules are available, a great deal of controversy still exists around the optimal approach for diagnosis. Approximately 20-30% of cytology...

Super Sensitive Sensor For The Detection Of Hydroxyl Free Radicals in Food

Project ID: D2020-04 Background: Detection of free radicals (ROS) is vital in maintaining food safety as the estimated economic damage caused by the impact on food safety is $7 billion per year in the US. The presence of ROS causes devastating effects on the food as it leads to oxidation of proteins, breakage of oligonucleotides, or irreparable altering...

Super Sensitive Sensor for the Detection of Hydroxyl Free Radicals

Project ID: D2020-04 Reactive oxygen species (ROS) are well known for their extreme reactivity. The impact of free radicals on medical and clinical fields is critical as hydroxyl radicals (OH) can be used as biomarkers for the detection of aging, cancer, Alzheimer’s, and Parkinson’s diseases. Because certain types of free radicals are known...

Telestroke Eye Examination Device

Project ID: D2019-08 Background: With the unprecedented Covid19 outbreak, Telehealth's need is more than ever, and the expected Telehealth market is at $72 billion by 2027. With the rise of 5G network technology, doctors are now able to perform telesurgery uninterrupted and seamless. Currently, ischemic stroke is the leading cause of adult...

Methods for detecting exposure to cyantoxins

Project ID: D2018-46Background Harmful Algal Blooms (HAB) are becoming more frequent worldwide due to factors such as temperature increase and pollution. Microcystins (MC) are carcinogenic toxins released by the algae during a blooms. MC exposure can occur via skin contact, inhalation, and ingestion and can cause illness in people and animals. MC detection...