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Project ID: TECH2026-05 Background Lyme disease is caused by the gram-negative spirochete Borrelia burgdorferi, as well as other Borrelia species within the Borrelia burgdorferi sensu lato group. B. burgdorferi is known to alter its virulence protein expression profiles depending on its environment. Numerous studies have shown environmental differences...

Connectors for joining aluminum plates

Project ID: D2018-49 Background Joining aluminum and other metal sheets using conventional processes can be problematic. Resistance spot welding (RSW) can expel molten metal, introduce voids/cracks and gas pockets, cause distortion, residual stresses and overall reduced fatigue strength. Friction stir welding (FSW) leaves an exit hole, requires...

Point of Care Ultrasound (POCUS) Real-Time 3D or Multi-Plane 2D Ultrasound Imaging Based on Bessel or Focused Beam Steered by a Reflector Driven by Electromagnets or Micro-Motors

Project ID: TECH-2025-34 Background: Despite that there are many companies that develop POCUS devices, many have so many problems with good images, short battery life, heating issues and no 3D images. Traditionally, a one-dimensional (1D) array transducer is used for two-dimensional (2D) imaging, where the transducer and its cable are heavy and bulky,...

Minimally Invasive Thrombectomy Device

Project ID: D2017-42 Background Many vascular system problems stem from insufficient blood flow. One of the main causes is a blockage within veins known as a blood clot, or thrombus. This can occur due to different phenomenological reasons. The ultimate goal of any percutaneous modality to treat these conditions of the arterial or venous system...

Rectal Retractor for damage-prevention during radiation therapy

Project ID: D2016-57 + D2018-64 Background Effective radiation treatment delivers the maximum possible dose to a tumor while minimizing radiation exposure to the surrounding healthy tissue. Curative doses of radiation can induce chronic morbidities in nearby critical structures. For most cancers in the pelvic region, the dose-limiting organ is the...

Portable Microlens Enhanced Multi-Modal Imaging and Sensing Platform

Project ID: TECH2025-15 Background Imaging and biosensing devices are used worldwide for a wide variety of applications from research to healthcare to environmental monitoring. However, these measurements become challenging in resource-limited settings such as remote areas or villages in third-world countries. In resource-limited settings, traditional...

Plate & Strap Immobilizer

Project ID: TECH2025-07 Background Hand restraints are commonly used in medical settings to limit the movement of a patient’s hands or arms, particularly when there is a risk of self-harm, interference with medical procedures, or disruption of treatment. These devices are important in ensuring patient safety, preventing accidental removal...

Super-Directive Huygens Antennas based on Crossed Electric and Magnetic Dipoles

Super Directive Huygens Antenna Project ID: D2025-11 Background The antenna industry has experienced substantial growth in recent years due to escalating demands for high-speed connectivity and the proliferation of smart devices. Traditional patch antennas, which are widely used because of their low profile and ease of fabrication, typically achieve...

Novel tasquinimod analogs having novel anticancer activity

Project ID: TECH-2025-31 Background Disruption of microtubules has dramatic effects on cell division due to the essential role they play in conjunction with the mitotic spindles during this process. Molecules that disrupt microtubule function are currently in widespread clinical use in cancer treatment. Taxanes, vinca alkaloids, and epothilones are...

PTH1R PROTAC

Project ID: TECH-2025-20 Background Every 16 mins a man will die of Prostate cancer. Bone metastasis is the predominant cause of morbidity and mortality in prostate cancer, with > 80 % of lethal cases exhibiting skeletal involvement. Parathyroid hormone-related protein (PTHrP), secreted by tumor cells, binds and activates PTH1R on osteoblasts and...

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