A Novel Process to Coat Implant Surfaces with Bi-Functional Bioactive Antibacterial Coatings


Project ID:  D2017-07



In the orthopedic field, there is a need for improved capabilities for creating strong osseointegration at bone-implant interfaces and treating bacterial infections. Implant-related infections occur in 0.75% in hip implants and 1.5% in knee implants resulting in reduced lifespan and increased failure rate of prosthesis, second surgeries, etc. Infections arise from the “race to the surface” concept in which bacteria and host cells compete to adhere and colonize the implant. Antibacterial coatings have been developed to prevent bacterial biofilm formation, thus promoting host cells adherence. However, current deposition techniques have drawbacks, such as cost-effectiveness and the use of high temperatures that degrades the substrate surfaces. Therefore, there is a need for a simple, cost effective and industrial viable technique suitable for all implants.


Invention Description

The researchers at the University of Toledo have developed an implant coating that is osseointegrable and an antibacterial. It includes a method to prepare an implantable article comprised of a biocompatible substrate (polymeric or ceramic) to accept a very thin biocompatible, bioactive coating material to facilitate bio-ingrowth between the substrate and bone or cartilage tissue. The substrate is a hydroxyapatite phosphate material doped with a metal and subsequently coated with a metal containing phosphate via microwave radiation.



•       Bone fractures treated with wires, nails, screws, and plates; joints replaced by artificial endoprostheses; dental implants; other.

•       Implant antibacterial coating



•       BIOACTIVE + BIOCOMPATIBLE: Technology produces a biocompatible and bioactive form of calcium phosphate coating which will degrade and facilitate bone formation for faster patient healing and recovery.

•       Forms direct bonds to newly formed bone tissue in the body

•       Features biochemical and biomechanical properties suitable for load bearing orthopedic implants

•       No degradation in-vivo;

•       VERSATILE: Efficiently coats polymers and other substrates, including PEEK.

•       FASTER PROCESSING TIME: Commercially efficient processing time. Newly developed technology performs the coating process within minutes to a few hours thus allowing for converting the batch process to a continuous process.

•       Coating kinetics are accelerated from 3 weeks to minutes by the use of microwave irradiation

•       Uniform coating with controlled release of metal ions

•       Lower processing temperature than current techniques

•       Lower material costs than current techniques


IP Status:       US Utility, 20180289858A1


Publications:       1. Ren Y, Babaie E, Bhaduri SB. Microwave-assisted magnesium phosphate coating on the AZ31 magnesium alloy. Biomed Mat. 2017 Aug 18; 12(4)

                             2. Sikder P, Ren Y, Bhaduri SB. Synthesis of Bifunctional Coatings on Ti6Al4V Implants by Rapid Microwave Irradiation Technique. Presented at the Conference Tools for Materials Science & Technology. 2017.


Patent Information:
For Information, Contact:
Katherine Pollard
Licensing Associate
The University of Toledo
Sarit Bhaduri
Vijay Goel
Yufu Ren
Prabaha Sikder
Bone healing