Concurrent Delivery of Interstitial Thermobrachytherapy in Cancer Treatment


Project ID:  D2017-09



Brachytherapy is a minimally invasive treatment that allows a dose of radiation to be delivered to a defined treatment area using a radioactive source or seed. Addition of hyperthermia to brachytherapy enhances treatment in certain types of cancer, especially if it is delivered in conjunction with the radiation therapy through interstitial ferromagnetic implants. One disadvantage of this treatment method, however, is that combining brachytherapy and hyperthermia results in a dramatic increase in the number of implants in order to account for both types of seeds. This results in more trauma to the patient. 


Invention Description

Researchers from The University of Toledo have developed a cancer treatment technique using a newly developed multi-purpose radioactive seed for concurrent delivery of hyperthermia and brachytherapy to solid tumors. The current technology is in contrast to current clinically available technology where hyperthermia is delivered by microwave and ultrasound applicators resulting in limited penetration and the inherent need for invasive thermometry.



•       The technology may be used in the treatment of cancers, especially solid tumors where concurrent hyperthermia and brachytherapy is needed



•       This technology increases the penetration of radiotherapy in cancer treatment

•       A ceramic ferrite core used in this technology may serve as a self-regulating source of hyperthermia


IP Status:       Patent Issued (US 9,750,954)


Publications:       Warrell G et al., Use of novel thermobrachytherapy seeds for realistic prostate seed implant treatments. Medical Physics, 2016, 4311 6033


Patent Information:
For Information, Contact:
Kwaku Opoku
Licensing Associate
The University of Toledo
E. Parsai
Diana Shvydka
Gregory Warrell