Search Results - cancer

9 Results Sort By:
Enhanced Immunogenicity Vaccine Development Platform
Project ID: D2012-14BackgroundExtensive research is being carried out globally to develop vaccines for the treatment of different types of infections and diseases. However, improved immunogenicity and efficient delivery of antigens to the antigen producing cells (APCs) via these vaccines is still a challenge. Also, it is very costly and time consum...
A new class of HDAC inhibitors with a new metal-binding group
Project ID: D2018-08Background Cancer is group of diseases characterized by uncontrolled growth of abnormal cells. Selectivity towards cancer cells has been challenging, resulting in treatment options with severe side effects. Histone deacetylases (HDAC) are highly expressed in cancer cells and have been investigated for cancer drug development. O...
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Immunostimulatory adjuvant molecules and antibody recruiting molecule-containing lipopeptide vaccines
Project ID: D2017-06Background Protein conjugate vaccines have limitations due to the innate immunogenicity of carrier proteins that can suppress the response against associated antigens. Thus, the development of fully synthetic vaccines have been under intense investigation in the last decade in immunotherapy. A typical fully synthetic vaccine in...
Concurrent Delivery of Interstitial Thermobrachytherapy in Cancer Treatment
Project ID: D2017-09Background Brachytherapy is a minimally invasive treatment that allows a dose of radiation to be delivered to a defined treatment area using a radioactive source or seed. Addition of hyperthermia to brachytherapy enhances treatment in certain types of cancer, especially if it is delivered in conjunction with the radiation thera...
“Sweet-P”: Molecule for Targeting Human Glucocorticoid Receptor Beta in Cancer
Project ID: D2016-49Background Glucocorticoids are the most prescribed anti-inflammatory drugs. They are also used in cancer therapies, and for their protective properties against the toxic effects of chemotherapy. Glucocorticoids may, however, cause resistance to platinum-based chemotherapeutics, resulting in the proliferation of cancer cells. The...
Novel Epothilone Analogues as Antileukemia Agents and Method Thereof
Project ID: PHR00107 Novelty: Conformationally restrained novel epothilone analogue exhibiting strong and selective growth inhibitory effect on leukemia cell lines. Background: Epothilones have been reported to exhibit potent anticancer activity and a number of epothilone analogs have entered clinical evaluation in humans (in addition to Epo B),...
Novel Non-ATP Competitive SRC Inhibitor for Treating Cancer
Project ID: D2009-07Background:P SRC kinase inhibitors have been clinically tested on a number of cancers. These inhibitors work by interrupting SRC’s role in tumor growth, proliferation, adhesion and motility. The most common method of inhibiting SRC is through an ATP analog, blocking the ATP binding site. However, ATP analogs have relat...
Engineered Protein Tames Bleeding In Haemophiliacs and Targets Angiogenesis in Cancer
Project ID: D2007-12 U.S. Patent #8,211,858; Canada, European patents pending U.S. Patent #7,592,422; Canada, France, Germany, Netherlands, UK patents pending Novelty: Modified plasminogen activator inhibitor type I (PAI- 1) with significantly increased in vivo half-life and decreased activity to urokinase plasminogen activator, tissue plasminog...