Description:
Project ID: D2016-29
IP Status: PCT patent application filed
Invention Description and Novelty: “Thin” molecules offer stronger binding to PPAR and include greater lipid burning and glucose lowering properties.
Applications: Dyslipidemia, obesity and type II diabetes
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)
Value propositions:
• Bilirubin reduces body fat percentage and glucose levels, but not in PPARα knockout mice.
• Thin molecules bind to PPARto decrease fat mass,
which results in the prevention of type II diabetes.
• In a humanized mouse model of hyperbilirubinemia, which typically have a moderate increase in plasma bilirubin levels (50%-1.5 fold elevations), we have observed reduced fat mass, increased lean mass, and lower plasma insulin and glucose levels when treated with Thin molecules.
• Compounds and methods described can be embodied in the form of a kit or kits.
• Next steps: Treat adipocytes during an adipogenesis assay to show the effect of Thin Molecules on lipid accumulation. Then, treat mouse models of obesity and diabetes to show that the Thin Molecules can reduce fat mass and blood glucose levels.
• Compounds will provide competition for fibrate drug class that are ligands for PPAR, including Fenofibrate, Bexafibrate, Ciprofibrate, Clofibrate, Gemfibrozil, Clinofibrate.