Desmoglein 1 (18D4) Monoclonal Antibody


Project ID:  D1995-15b


Antigen Specificity: Desmoglein 1


Clone: 18D4


Specificity: Reacts with the 165 kDa desmoglein 1 protein. Also, it does not cross react with desmoglein 2 or desmoglein 3.


Host species: Mouse


Reactive species: Human



Desmoglein 1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.


Applications: Western blot, Immunofluorescence, Immunoprecipitation, Immunohistology - Frozen



1.     Wahl, J K III. Generation of monoclonal antibodies specific for desmoglein family members. Hybrid Hybridomics 2002, 21: 37

2.     Wu, H., Stanley, J.R. and Cotsarelis, G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol 2003, 120: 1052–1057.

Patent Information:
For Information, Contact:
Lokesh Mohan
Licensing Associate
The University of Toledo
James Wahl
Margaret Wheelock
Keith Johnson