Desmoglein 1 (18D4) Monoclonal Antibody

Description:

Project ID:  D1995-15b

 

Antigen Specificity: Desmoglein 1

 

Clone: 18D4

 

Specificity: Reacts with the 165 kDa desmoglein 1 protein. Also, it does not cross react with desmoglein 2 or desmoglein 3.

 

Host species: Mouse

 

Reactive species: Human

 

Description:

Desmoglein 1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

 

Applications: Western blot, Immunofluorescence, Immunoprecipitation, Immunohistology - Frozen

 

References:

1.     Wahl, J K III. Generation of monoclonal antibodies specific for desmoglein family members. Hybrid Hybridomics 2002, 21: 37

2.     Wu, H., Stanley, J.R. and Cotsarelis, G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol 2003, 120: 1052–1057.

Patent Information:
Category(s):
Research Tools
For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Stephen.Snider@utoledo.edu
Inventors:
James Wahl
Margaret Wheelock
Keith Johnson
Keywords: