Anti-Beta-Catenin (6F9) Monoclonal Antibody

Description:

Project ID:  D1995-12d

 

Antigen Specificity: Beta – catenin

 

Clone: 6F9

 

Host species: Mouse

 

Specificity: Recognizes beta-catenin (94kD) in immunoblotting. Does not cross-react with plakoglobin

 

Reactive species: Human, Cow, Dog

 

Description:

The monoclonal antibody 6F9 reacts with human and mouse beta-catenin. Beta-catenin, along with alpha-catenin and gamma-catenin, belongs to the family of catenins. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin, it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signalling and gene expression.

 

Applications: Western blot, Immunoprecipitation, Immunofluorescence

 

References:

1.     Knudsen KA, Soler AP, Johnson KR, Wheelock MJ. Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J Cell Biol. 1995; 130(1): 67-77

2.     Sacco, PA; McGranahan TM; Wheelock, MJ; Johnson, KR. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995, 270: 20201-6

 

Patent Information:
Category(s):
Research Tools
For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Stephen.Snider@utoledo.edu
Inventors:
James Wahl
Margaret Wheelock
Keith Johnson
Keywords: