P-Cadherin (6A9) Monoclonal Antibody

Description:

Project #:  D1995-19a

 

Antigen Specificity: P-Cadherin (Cadherin 3)

 

Clone: 6A9

 

Specificity: Reacts with ~120 KDa P-Cadherin protein

 

Host species: Mouse

 

Reactive species: Human

 

Description:

The 6A9 monoclonal antibody reacts with human P-Cadherin. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

 

Applications: Western blot, Immunofluorescence, Immunoprecipitation

 

References:

Hines, MD; Jin, HC, Wheelock, MJ; Jensen, PJ. Inhibition of cadherin function differentially affects markers of terminal differentiation in cultured human keratinocytes. J Cell Sci. 1999, 112 (Pt24):4569-79.

Patent Information:
Category(s):
Research Tools
For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Stephen.Snider@utoledo.edu
Inventors:
Margaret Wheelock
James Wahl
Keith Johnson
Keywords:
Antibodies