Project #: D1995-19b
Antigen Specificity: P-Cadherin (Cadherin 3)
Clone: 12H6
Specificity: Reacts with ~120 KDa P-Cadherin protein
Host species: Mouse
Reactive species: Human
Description:
The 12H6 monoclonal antibody reacts with human P-Cadherin. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
Applications: Western blot, Immunofluorescence