P-Cadherin (12H6) Monoclonal Antibody


Project #:  D1995-19b


Antigen Specificity: P-Cadherin (Cadherin 3)


Clone: 12H6


Specificity: Reacts with ~120 KDa P-Cadherin protein


Host species: Mouse


Reactive species: Human



The 12H6 monoclonal antibody reacts with human P-Cadherin. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.


Applications: Western blot, Immunofluorescence

Patent Information:
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For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Margaret Wheelock
Keith Johnson
James Wahl