Plakophilin-1 (10B2) Monoclonal Antibody


Project #:  D1995-20


Antigen Specificity: Plakophilin-1    


Clone: 10B2


Specificity: Reacts with the N-terminus of human plakophilin-1


Host species: Mouse


Reactive species: Human



Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.


Applications: Western blot, Immunofluorescence, Immunoprecipitation
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For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Margaret Wheelock
James Wahl
Keith Johnson