Project #: D1995-20
Antigen Specificity: Plakophilin-1
Clone: 10B2
Specificity: Reacts with the N-terminus of human plakophilin-1
Host species: Mouse
Reactive species: Human
Description:
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.
Applications: Western blot, Immunofluorescence, Immunoprecipitation