N-Cadherin (8C11) Monoclonal Antibody

Description:

Project #:  D1995-18a

 

Antigen Specificity: N-Cadherin (Cadherin 2)

 

Clone: 8C11

 

Specificity: Reacts with ~140 KDa N-Cadherin protein

 

Host species: Mouse

 

Reactive species: Human

 

Description:

The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 140 kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

 

Applications: Western blot, Immunofluorescence, Immunoprecipitation

 

References:

Wahl, JK III; Kim, YJ; Cullen, JM; Johnson, KR; Wheelock, MJ.  N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem. 2003, 278(19):17269-76

Patent Information:
Category(s):
Research Tools
For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Stephen.Snider@utoledo.edu
Inventors:
Margaret Wheelock
James Wahl
Keith Johnson
Keywords:
Antibodies