Desmoglein 3 (5G11) Monoclonal Antibody

Description:

Project #:  D1995-17b

 

Antigen Specificity: Desmoglein 3

 

Clone: 5G11

 

Specificity: Reacts with ~130 KDa desmoglein-3 protein

 

Host species: Mouse

 

Reactive species: Human

 

Description:

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

 

Applications: Western blot, Immunoprecipitation, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

 

References:

1.        Mahoney, MG; Hu, Y; Brennan, D; Bazzi, H; Christiano, AM; Wahl, JK III. Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. Exp Dermatol. 2006, 15(2):101-9

2.        Wahl JK III. Generation of monoclonal antibodies specific for desmoglein family members. Hybrid Hybridomics 2002, 21(1):37-44

Patent Information:
Category(s):
Research Tools
For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Stephen.Snider@utoledo.edu
Inventors:
Margaret Wheelock
James Wahl
Keith Johnson
Keywords:
Antibodies