Project #: D1995-12a
Antigen Specificity: Beta – catenin
Clone: 9F2
Host species: Mouse
Reactive species: Human, Mouse
Description:
The monoclonal antibody 9F2 reacts with human and mouse beta-catenin. Beta-catenin, along with alpha-catenin and gamma-catenin, belongs to the family of catenins. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin, it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signalling and gene expression.
Applications: Western blot, Immunoprecipitation, Immunofluorescence
References:
1. Johnson, KR; Lewis, JE; Li, D; Wahl, J; Soler, AP; Knudsen, KA; Wheelock, MJ. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252-60
2. Sacco, PA; McGranahan TM; Wheelock, MJ; Johnson, KR. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995, 270: 20201-6