Search Results - donald ronning

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Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Novel Fluorescent Probe and Assay for Quantifying Adenosine and Adenosyl-Containing Compounds in Solution
Project: D2014-24Novelty: Use of a novel fluorescent probe and a recombinant protein in development of in vitro assays for determination of adenosine concentration in biochemical reactions. Description: Researchers at the University of Toledo have developed a fluorescence polarization (FP) assay that uses nanomolar concentrations of a novel fluorescent...
E. Coli plasmid (pET32) encoding MTA/SAH nucleosidase
Project ID: D2011-29 Gene: ‘pfs’ gene from H. pylori (strain J99) genomic DNA Enzyme encoded: 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase Plasmid: pET32 Description: The bacterial enzyme 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) plays a central role in three essential metabolic pathways in...
M. Tuberculosis Drug Molecules Screening Assay
Project ID: D2011-63Novelty: The disclosed invention is a simple and efficient high-throughput assay to screen small molecule drug and drug-like compounds for their effectiveness against Mycobacterium Tuberculosis (M. tb) and other bacterium.Value Proposition:M. tb is a form of tuberculosis that is resistant to two or more of the primary drugs (e.g.,...