Search Results - Neuroscience

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Aspiration catheter with an adjustable tip for intracranial circulation
Project ID: D2021-08 Background: Acute ischemic stroke is the sudden blockage of adequate blood flow to a section of the brain, usually caused by thrombus or other emboli lodging or forming in one of the blood vessels supplying the brain. If the blockage is not quickly resolved, the ischemia may lead to permanent neurologic deficit or death. The...
Furoxans as Novel Therapeutics for Neurodegenerative Disorders
Project ID: D2017-15 Background Nitric oxide (NO) signaling plays a major role in brain activity and normal function of neurons. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetic, such as nitrates, have been used against a variety of neurological disorders. This is due to the...
Cofilin inhibitor for the treatment of hemorrhagic brain injury-induced inflammation
Project ID D2019-35 Background Cofilin regulates actin filament assembly and organization in most cells, including during macrophage, T-cell, and dendritic activation and migration. Over-activation of cofilin can lead to microglia inflammation in the brain. Although Cofilin has been shown to be involved in the secondary injury of intracerebral hemorrhage...
Targeting mDia formins to halt tumor microtube formation, invasion, and proliferation in brain tumors
Project ID D2019-34 Background Tumor therapies must overcome complex obstacles, such as cellular invasion, chemoresistance, and radioresistance. Cells within a brain tumor often form specialized ultralong cellular projections called tumor microtube (TM) projections that allow them to invade new areas of the brain. The networks formed by TMs interconnect...
Novel compound in treating autophagy-related pathologies
Project IDs: D2015-09 and D2016-81Background:Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy...
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model of...
Sensor and assay for screening of photosensitizers in living cells
Project ID: D2018-33Background Photodynamic therapy (PDT) uses light and a photosensitizer in the presence of oxygen to elicit cell death. This technique has been under investigation for use in treatment of cancerMost often used to treat skin cancer, mycosis fungoides, and non-small cell lung cancer. Researchers need to detect the ability of PDTs to...
Treatment of Ischemic Stroke with ROS-Sensitive Nitric Oxide Synthase Inhibitors
Project ID: D2018-11Background Nearly 800,000 people in the United States suffer a stroke every year, with about 87% of the strokes being classified as ischemic. Ischemic stroke is caused by blockage of blood flow to the brain, which results in neuronal and glial hypoxia and, subsequently, inflammatory and free radical-mediated cell death. Reactive...
Muscarinic Agonists for the Treatment of Autism Spectrum Disorder
Project ID: D2011-54Background Autism Spectrum Disorder (ASD) describes a group of developmental disorders that is often characterized by persistent repetitive and restrictive behaviors and deficits in social communication that, overall, affect the ability of the individual to functional normally in a social setting. Although early treatment and care...
Novel agents and methods for treating neurodegenerative disorders
Project ID: D2013-69IP Status: Utility patent application filed Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof. Applications: Compositions comprising midi and/or mini-GAGR have been...