Search Results - Cardiovascular%2c+Renal%2c+%26+Metabolism

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One Step Aortic Puncher
Project Id: D2022-31 Background Patients with coronary artery disease develop this disease often over a course of decades. Deposits high in cholesterol, commonly referred to as plaque, builds up in the coronary arteries causing inflammation. This disease tends not to be noticeable until significant blockage or a heart attack occurs. Coronary bypass...
Cofilin inhibitor for the treatment of hemorrhagic brain injury-induced inflammation
Project ID D2019-35 Background Cofilin regulates actin filament assembly and organization in most cells, including during macrophage, T-cell, and dendritic activation and migration. Over-activation of cofilin can lead to microglia inflammation in the brain. Although Cofilin has been shown to be involved in the secondary injury of intracerebral hemorrhage...
PEGylated Bilirubin for the treatment of Hyperlipidemia, Obesity, and Type II Diabetes
Project ID: D2018-40Background:Obesity, a low-grade inflammatory disease, has affected more than 150 million people in the US. Obesity and its associated risk factors are a prelude to the development of type II diabetes that accounts for a vast majority of the 25.8 million diabetes cases in the US. Bilirubin, a yellow pigment produced during red blood...
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model of...
Use of Small Molecule Inhibitors as Anti-Thrombotic Agents
Project: D2016-03IP Status: PCT filed Invention Description: Discovery of a new family of small molecules that can be used to decrease the risk of thrombosis in patients with several diseases. Novelty: The most important aspect of this new antithrombotic is that it prevents the transition of platelets to a hypersensitive state without impacting normal...
“Thin” Molecules for Treating Obesity and Type II Diabetes
Project ID: D2016-29IP Status: PCT patent application filedInvention Description and Novelty: “Thin” molecules offer stronger binding to PPAR and include greater lipid burning and glucose lowering properties. Applications: Dyslipidemia, obesity and type II diabetes Value propositions: • Bilirubin reduces body fat percentage and...