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Novel Compounds in Treating Autophagy-Related Pathologies

Project IDs: D2015-09 and D2016-81 Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy often...

Use of fluorescent ANTS to examine the BBB-permeability of polysaccharide

Project ID: D2015-27Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof.Applications: Compositions comprising midi and/or mini-GAGR have been shown to be useful for treatment of neurodegenerative...

Novel agents and methods for treating neurodegenerative disorders

Project ID: D2013-69 Midi-GAGR has several desired properties (neurotrophic, anti-oxidant, non-cytotoxic, anti-inflammatory, and BBB-permeable) for treatment of neurodegenerative diseases. Such materials have been shown to cross the blood-brain barrier, reduce the degeneration of cortical, peripheral, and dopaminergic nerve cells under pathogenic...