http://utoledo.technologypublisher.comBe the first to know about the latest inventions and technologies available from The University of Toledoen-USSun, 15 Mar 2026 01:26:18 GMTTue, 10 Mar 2026 06:42:06 GMThttp://blogs.law.harvard.edu/tech/rssjackie.wilkinson@utoledo.eduCopyright 2026, The University of ToledoTECH-2026-01http://utoledo.technologypublisher.com/technology/60726Project ID: TECH2026-01 Background Polycystic Kidney Disease (PKD) affects 1 in 500 people. Half of PKD of patients reach kidney failure by age 50. Annual U.S. healthcare costs exceed $120 billion. There is currently no cure and a few affective treatments. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the progressive development of renal cysts, which ultimately leads to end-stage renal disease (ESRD). ADPKD affects over 600,000 people in the United States and over 12 million people worldwide, with no cure currently available. The hallmark of the...Tue, 10 Mar 2026 06:42:06 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/60726TECH-2026-20http://utoledo.technologypublisher.com/technology/60725Project ID: TECH2026-20 Background Approximately 4 million people worldwide die each year from traumatic injuries, with an estimated 30-40% caused by hemorrhage. A significant portion of hemorrhage-related deaths involve extremity bleeding. A tourniquet is a device designed to apply firm, circumferential pressure around a limb. Its purpose is to temporarily stop blood flow to and from the area distal to where it is placed. Tourniquets assist with severe bleeding by compressing major arteries in the arm or leg, which halts blood loss when direct pressure is not enough, buying time until defin...Tue, 10 Mar 2026 06:35:12 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/60725TECH-2026-03http://utoledo.technologypublisher.com/technology/60367Fri, 13 Feb 2026 11:04:05 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/60367TECH-2026-05http://utoledo.technologypublisher.com/technology/59680Fri, 19 Dec 2025 07:29:23 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/59680D2018-49http://utoledo.technologypublisher.com/technology/58689Fri, 26 Sep 2025 08:05:06 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/58689TECH-2025-34http://utoledo.technologypublisher.com/technology/58341Project ID: TECH-2025-34 Background: Despite that there are many companies that develop POCUS devices, many have so many problems with good images, short battery life, heating issues and no 3D images. Traditionally, a one-dimensional (1D) array transducer is used for two-dimensional (2D) imaging, where the transducer and its cable are heavy and bulky, and only a single slice of an image of the heart can be acquired at each transducer position. Although a 2D array transducer can be used to acquire three-dimensional (3D) images, it is heavier and bulkier. Considering the importance of accurac...Tue, 26 Aug 2025 06:19:46 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/58341D2017-42http://utoledo.technologypublisher.com/technology/57993Fri, 11 Jul 2025 06:39:54 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57993D2018-64http://utoledo.technologypublisher.com/technology/57992Fri, 11 Jul 2025 06:12:13 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57992TECH-2025-15http://utoledo.technologypublisher.com/technology/57990Fri, 11 Jul 2025 05:58:33 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57990TECH-2025-07http://utoledo.technologypublisher.com/technology/57683Thu, 26 Jun 2025 07:38:34 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57683TECH-2025-11http://utoledo.technologypublisher.com/technology/57668Tue, 24 Jun 2025 13:37:40 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57668TECH-2025-31http://utoledo.technologypublisher.com/technology/57648Project ID: TECH-2025-31 Background Disruption of microtubules has dramatic effects on cell division due to the essential role they play in conjunction with the mitotic spindles during this process. Molecules that disrupt microtubule function are currently in widespread clinical use in cancer treatment. Taxanes, vinca alkaloids, and epothilones are among the most commonly used anti-mitotic cancer drugs. However, anti-mitotics can have significant dose-limiting toxicities. Therefore, more selectively active and less toxic molecules that disrupt microtubule function are desired. There is a nee...Mon, 23 Jun 2025 07:10:07 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57648TECH-2025-20http://utoledo.technologypublisher.com/technology/57522Mon, 09 Jun 2025 12:12:30 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57522D2020-28http://utoledo.technologypublisher.com/technology/57489Wed, 04 Jun 2025 07:06:21 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/57489D2018-06http://utoledo.technologypublisher.com/technology/56602Thu, 27 Mar 2025 06:36:22 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/56602D2019-01http://utoledo.technologypublisher.com/technology/55973Mon, 13 Jan 2025 13:09:10 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55973D2013-02http://utoledo.technologypublisher.com/technology/55917Thu, 02 Jan 2025 13:11:40 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55917D2009-05http://utoledo.technologypublisher.com/technology/55680Mon, 25 Nov 2024 12:39:09 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55680D2018-09http://utoledo.technologypublisher.com/technology/55665Thu, 21 Nov 2024 11:52:37 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55665D2012-27http://utoledo.technologypublisher.com/technology/55617Fri, 15 Nov 2024 07:31:11 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55617TECH-2024-27http://utoledo.technologypublisher.com/technology/55470Tue, 29 Oct 2024 06:19:17 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55470TECH-2024-13http://utoledo.technologypublisher.com/technology/55462Fri, 25 Oct 2024 11:43:56 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55462TECH-2024-15http://utoledo.technologypublisher.com/technology/55314Solid Supports for Sorptive Thin Films Background Sorptive Thin Films have found broad applicability as a separation method that allows for the isolation of organic molecules from aqueous samples, air and semisolids. In the field of analytical extractions, sorptive thin films are applied to techniques such as Thin-Film Solid Phase Microextraction (SPME) and Fabric Phase Sorptive Extraction (FBSE), which have greatly improved extraction performance and throughput over traditional arrow and fiber technologies and dispersive or flow-through extraction methods. Current film holders present techn...Thu, 10 Oct 2024 12:50:37 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55314TECH-2024-26http://utoledo.technologypublisher.com/technology/55147Project ID: TECH2024-26 Background Shear thickening refers to the phenomenon in rheology where the viscosity of a fluid increases as the rate at which the fluid is deformed by a shearing force (i.e., the shear rate) increases. When more force is applied to the fluid, the fluid becomes more resistant to flow. Shear thinning is when the viscosity decreases as the shear rate increases. Both shear thickening and shear thinning occur in non-Newtonian fluids as they have shear-dependent viscosity. Shear thickening can complicate processing operations in numerous ways. Specifically, in the cerami...Mon, 16 Sep 2024 11:09:29 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55147TECH-2024-30http://utoledo.technologypublisher.com/technology/55033Project ID: TECH2024-30 Background Membranes for ultrafast oil/water separations are useful and necessary in a lot of different fields such as the oil/water separation market, the superhydrophobic membranes/coatings market (SAM), the membrane separation market (TAM), separation technologies, cleaning industries, oil spill remediation, corrosion control, and the hydrophobic membrane market which includes oil and gas industries (oil/water separations), electronics, packaging (weather proofing), clothing (safety gear, personal protection equipment), and waste water treatment. There is a need...Wed, 04 Sep 2024 11:24:04 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/55033TECH-2023-37http://utoledo.technologypublisher.com/technology/54793Tue, 30 Jul 2024 11:59:14 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/54793TECH-2024-20http://utoledo.technologypublisher.com/technology/54791Tue, 30 Jul 2024 10:51:48 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/54791TECH-2024-17http://utoledo.technologypublisher.com/technology/54653Mon, 15 Jul 2024 13:04:26 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/54653TECH-2024-07http://utoledo.technologypublisher.com/technology/54241Tue, 21 May 2024 12:18:46 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/54241TECH-2024-12http://utoledo.technologypublisher.com/technology/54240Tue, 21 May 2024 11:43:07 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/54240D2005-01http://utoledo.technologypublisher.com/technology/54151D2005-01 Background Capillary leakage of important ions and proteins, such as albumin from blood vessels can lead to a buildup of fluid in interstitial space (organ swelling) as well as hypoperfusion of organs. Capillary leak (CL) is a central component of multiorgan failure and a secondary component to severe sepsis caused by bacterial or viral infections, systemic inflammatory response syndrome (SIRS), and acute respiratory distress syndrome (ARDS). Systemic inflammation causes endothelial cell injury and cytokine release that exacerbates the CL. Current treatments utilize vasopressors and ...Wed, 08 May 2024 12:47:07 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/54151TECH-2023-34http://utoledo.technologypublisher.com/technology/53522Project ID: TECH2023-34 Background Several studies have been conducted over the last few decades on the physical properties and chemical composition of the sea-surface microlayer as well as its chemical exchange processes at the air/sea interface. As a result of these studies, it has been demonstrated that a wide variety of xenobiotics are accumulated on the sea surface. Organic contaminants are more likely to accumulate on the sea surface due to their hydrophobic or surfactant properties. It has been reported that organic pollutants are present not only on the surface but also in ocean dept...Fri, 01 Mar 2024 12:00:39 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/53522TECH-2024-09http://utoledo.technologypublisher.com/technology/53043Project ID: TECH2024-09 Background High image resolution is a desired outcome in wave-related disciplines such as ultrasound, acoustics, optics, and electromagnetics. However, the spatial resolution of an imaging system is fundamentally limited by the spatial frequency of the point spread function (PSF) of the system due to diffraction. There have been numerous methods developed over past few decades for super-resolution imaging (SRI) to break the diffraction limit, but most of these methods are very specific and are not generally applicable in different areas of science and engineering. In ...Tue, 09 Jan 2024 12:51:44 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/53043D2021-13http://utoledo.technologypublisher.com/technology/52893Thu, 07 Dec 2023 10:41:28 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/52893TECH-2023-19http://utoledo.technologypublisher.com/technology/52892Thu, 07 Dec 2023 10:37:21 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/52892TECH-2023-20http://utoledo.technologypublisher.com/technology/52539Project ID: TECH-2023-20 Background Wet wipes have been shown to clog pipes and pumps in wastewater collection and treatment systems. Additionally, wet wipes contain microplastics that contribute to water pollution. Some governments are proposing restrictions or complete bans on wet wipe products. Therefore, there is a need for a truly flushable wet wipe that does not cause water pollution. Invention Description Researchers at the University of Toledo developed a solution to reinforce toilet paper with a natural biopolymer gel that dissolves in excess water. This biopolymer is used as a ...Wed, 04 Oct 2023 13:53:57 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/52539TECH-2023-28http://utoledo.technologypublisher.com/technology/52323Project ID: TECH-2023-28 Background Pelvic organ prolapse (POP) occurs when a pelvic organ slips from the normal position and down into the rectum or vagina. Patients can alleviate symptoms by inserting a pessary into the vagina to hold an organ in its normal position. This can be a great alternative to risky surgeries but is challenging or impossible to use during menstruation. Therefore, there is a need for a pessary device that can also function as a menstrual cup. Invention Description Bioengineers from the University of Toledo developed a device that is configured to combine the f...Tue, 22 Aug 2023 13:52:01 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/52323D2010-12http://utoledo.technologypublisher.com/technology/52316Project ID: D2010-12 Background Diabetes mellitus is a disease in which an individual has difficulty regulating their blood glucose levels, in which extremely low or high glucose concentrations can occur. Normal physiological blood glucose ranges are generally between 80-120 mg/dL; however, diabetics commonly have blood concentrations from 50-500 mg/dL if not properly treated. The key to treating diabetes through therapy is to frequently monitor blood glucose concentrations, such that corrective actions can be taken. Currently, invasive approaches involve pain and increased risk that requir...Mon, 21 Aug 2023 08:48:03 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/52316D2022-18http://utoledo.technologypublisher.com/technology/52305Project ID: D2022-18 Background Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors that are located in the cell membranes of neurons and mediate the effects of the neurotransmitter acetylcholine (ACh). Each mAChR forms a complex with intracellular G proteins that, when activated, produce an intracellular signaling cascade. Each mAChR subtype features two types of ligand binding, via orthosteric and allosteric sites. The orthosteric site is primarily responsible for receptor activation by the endogenous ligand (ACh) and other orthosteric agonists. Ligand binding to a...Fri, 18 Aug 2023 07:20:45 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/52305D2022-28http://utoledo.technologypublisher.com/technology/51437Mon, 03 Jul 2023 11:21:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/51437D2010-06http://utoledo.technologypublisher.com/technology/51132Fri, 19 May 2023 08:44:47 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/51132TECH-2023-25http://utoledo.technologypublisher.com/technology/51014Project ID: TECH-2023-25 Background Histone Deacetylases (HDACs) have been studied extensively for their role in regulating expression of genes and proteins involved in cancer cell proliferation and migration. The Zinc Binding Group (ZBG) is an essential component of the HDAC inhibitor pharmacophore. It binds to the zinc ion in the enzyme active site and inhibits the enzyme. Three of the four HDAC inhibitors approved by the FDA have hydroxamic acid as the ZBG. However, hydroxamates have poor pharmacokinetic properties and the hydroxamatic acid is a highly promiscuous metal-binding group whi...Fri, 12 May 2023 07:08:53 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/51014D2022-12http://utoledo.technologypublisher.com/technology/51012Project ID: D2022-12 Background Chronic liver disease (CLD) exerts a huge economic burden causing 3.5% of deaths worldwide mainly due to poor early diagnosis of the disease. COVID-19 has also contributed a moderate impact causing further burden to CLD diagnosis. Cholemia and cholestasis are pathological conditions related to liver disorders with excess of bile acids in the blood. One unique feature of cholestasis is jaundice with abnormally elevated levels of bilirubin as well as bile acids in the blood, whereas in cholemia, only bile acids but not bilirubin is elevated in the blood. While ...Thu, 11 May 2023 13:52:10 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/51012D2022-32http://utoledo.technologypublisher.com/technology/50917Wed, 26 Apr 2023 07:09:21 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/50917D2022-11http://utoledo.technologypublisher.com/technology/50825Project ID: D2022-11 Background Multilayer packaging consists of thin layers of materials adhered on top of one another. The composition of layers is chosen based on performance needs, such as protection from moisture, oxygen, light, odor, flavor, or abrasion. Although these varying material properties contribute to performance advantages, they also interfere with the separation techniques that are leveraged in the recycling process. Current methods of recycling multilayer packaging require deviations from a typical recycling plant, such as requiring antisolvent recovery steps or high conce...Thu, 13 Apr 2023 12:01:23 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/50825TECH-2023-10http://utoledo.technologypublisher.com/technology/50672Project ID: TECH-2023-10 Background Size exclusion chromatography (SEC) is the preferred method to isolate and purify exosomes and extracellular vesicles. However, this technique is labor-intensive, requiring the operator to pipette samples, buffer, and wash into individual columns. Current solutions attempt to automate fraction collection, but still require the operator to pipette liquids and be present at the machine to instruct it to move to the next stage. Therefore, there is a need for a fully automated fraction collection instrument. Invention Description Researchers at the Univers...Wed, 22 Mar 2023 07:06:24 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/50672D2018-45http://utoledo.technologypublisher.com/technology/50388​​​​​Background Breast cancer is the leading cause of cancer-related deaths in women worldwide, and triple negative breast cancer (TNBC) accounts for approximately 15-20% of these cancers. TNBC tumors do not express three key therapeutically relevant cell-surface receptors: estrogen receptor (ER), progesterone receptor (PR), and overexpression of the human epidermal growth factor receptor 2 (Her2). The absence of these receptors significantly decreases treatment success since most of the currently approved breast cancer treatments mainly target one of the receptors. Furthermore, TNBC tumors h...Fri, 17 Feb 2023 12:39:16 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/50388D2022-15http://utoledo.technologypublisher.com/technology/50204Project ID: D2022-15 Background Ferroptosis is a non-apoptotic cell death mechanism impelled by unrestrained accumulation of iron-dependent cellular reactive oxygen (ROS) species leading to membrane lipid peroxidation resulting from intra-cellular antioxidant depletion. Clinical application of ferroptosis agents/drugs has been elusive due to off-target effects leading to drug toxicity 11. Improved understanding of protein targets and the mechanism of action of ferroptosis agents can contribute to their successful clinical application. Thus, there is a need for novel nontoxic and highly sele...Thu, 26 Jan 2023 07:35:58 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/50204D2022-31http://utoledo.technologypublisher.com/technology/50146Wed, 18 Jan 2023 13:09:32 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/50146D2022-16http://utoledo.technologypublisher.com/technology/48651Thu, 20 Oct 2022 08:13:43 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/48651D2013-77http://utoledo.technologypublisher.com/technology/48600Project ID: D2013-77 Background The rising concern around the sustainability of petrochemicals are prompting searches for more environmentally friendly and inexpensive feedstocks. Bio-based alternatives are attractive, but also require microbial fermentation. Enzyme hydrolysis is a promising way to reduce the cost of the pretreatment process. Invention Description Researchers at the University of Toledo have developed a way to make bio-based products from microalgae. The feedstock is treated with protease and amylase which separates the biomass into an organic phase containing lipids and...Mon, 10 Oct 2022 11:39:57 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/48600D2021-48http://utoledo.technologypublisher.com/technology/48599Project ID: D2021-48 Background Bone loss is one of the common symptoms associated with normal aging and pathologies. An increased bone mass loss and mineral density are the primary reason for osteoporosis, arthritis, fractures, etc. Together it affects millions of individuals in the US alone. While several drugs targeting the prevention of bone loss have been in clinical use, they are biological treatments that need to be injected regularly, last a short time, and need to be combined with additional anti-resorptive drugs. Therefore, there is a need for new drugs that promote bone growth. D...Mon, 10 Oct 2022 11:29:32 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/48599D2022-17http://utoledo.technologypublisher.com/technology/48507Thu, 22 Sep 2022 11:49:37 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/48507D2022-24http://utoledo.technologypublisher.com/technology/48110Tue, 23 Aug 2022 08:53:13 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/48110D2022-07http://utoledo.technologypublisher.com/technology/48103Tech ID: D2022-07 Urethral catheterization is a common medical practice for a variety of problems that require long-term catheterization such as retention of urine, urinary dysfunction, neurogenic bladder, pelvic floor dysfunction, and enlarged prostate. A conventional urinary catheter design generally includes a tip and a side opening at a distal end of the catheter where the tip is stiff, rigid and firm, thus the stiff tip penetrates the bladder wall causing mucosal tears and edema in the wall of the urinary bladder and thus, causing significant bladder pain and spasm, along with an increas...Mon, 22 Aug 2022 11:49:12 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/48103D2021-45http://utoledo.technologypublisher.com/technology/46576Project ID: D2021-45 Background: With increasing use of embolization in minimally invasive surgical procedures, the demand for microcatheters has increased exponentially and the growth rate is at 8%. Arteriovenous malformations (AVMs) are abnormal connections between arteries and veins in the brain or spine. The distinguishing feature of an AVM is that shunting occurs through a collection of tortuous dysmorphic vessels, referred to as a nidus. AVMs are difficult or dangerous to treat and may cause bleeding into or around the brain. Treatment for an AVM involves partial or complete closure of...Thu, 05 May 2022 12:40:40 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/46576D2016-76http://utoledo.technologypublisher.com/technology/46546Mon, 02 May 2022 06:46:05 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/46546D2017-25http://utoledo.technologypublisher.com/technology/45875Mon, 07 Feb 2022 07:06:25 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/45875D2014-42http://utoledo.technologypublisher.com/technology/45874Mon, 07 Feb 2022 06:57:24 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/45874D2021-25http://utoledo.technologypublisher.com/technology/45619Wed, 12 Jan 2022 10:43:12 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/45619D2020-06http://utoledo.technologypublisher.com/technology/45578Tue, 04 Jan 2022 08:32:41 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/45578D2021-40http://utoledo.technologypublisher.com/technology/45386Project Id: 2021-40 Background: Inferior vena cava (IVC) filters are small, metal devices temporarily placed in the inferior vena cava that are designed to catch blood clots and stop the blood clots from traveling to the lungs. An average of 65,000 IVC filters are placed annually in the United States. About 15% of the time, the IVC filter becomes embedded in the intima of the vessel, rendering it irretrievable by conventional methods such as the snare method. These filters are needed in patients with a history or risk of deep vein thrombosis (DVT) or pulmonary embolism (PE), as well as traum...Thu, 18 Nov 2021 07:20:57 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/45386D2021-33http://utoledo.technologypublisher.com/technology/44966Thu, 23 Sep 2021 12:24:17 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44966D2021-31http://utoledo.technologypublisher.com/technology/44965Project ID: D2021-31 Background Every year, about 200,000 people in the United States are diagnosed with an abdominal aortic aneurysm (AAA). In general, endovascular aortic aneurysm repair (EVAR) is the standard of care for AAA. However, about 20-30% of AAA patients are not eligible for standard EVAR. People who are not candidates for EVAR can be treated with open repair, which is a very high risk procedure with elevated levels of perioperative complications that may not be compatible with some frail patients. The other option is treatment with a custom-made fenestrated or branched endovascu...Thu, 23 Sep 2021 12:13:19 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44965D2021-29http://utoledo.technologypublisher.com/technology/44708Fri, 20 Aug 2021 08:47:04 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44708D2021-42http://utoledo.technologypublisher.com/technology/44382Project ID: D2021-42 Background Cell death and immortality are closely associated with cancer and cancer therapeutics, as oncogenesis requires a compromise of apoptosis while most cancer therapies depend on apoptopsis. Precise regulation of programmed cell death (apoptosis) is essential for cellular and organ homeostasis. Hyperactive apoptosis is associated with human diseases such as myocardial infarction, ischemic stroke, and immunodeficiency. In contrast, dysfunctional apoptosis is highly relevant to oncogenesis and, also, cancer treatment. While the mechanisms regulating apoptotic pathwa...Fri, 30 Jul 2021 12:04:14 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44382D2021-28http://utoledo.technologypublisher.com/technology/44360Project ID: D2021-28 Background The United States Pharmacopeial Convention has published the standard, USP 800, for handling hazardous drugs in healthcare settings. The National Institute for Occupational Safety and Health (NIOSH) has recommended that caregivers use an effective Closed System Transfer Device (CSTD) in order to minimize exposure to hazardous drugs and limit their adverse effects. The CSTD design mechanically prohibits the escape of fluid and vapors outside of its system. However, more than one CSTD is usually needed, and spillage occurs while changing devices. This is both u...Wed, 28 Jul 2021 05:49:47 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44360D2020-22http://utoledo.technologypublisher.com/technology/44086Project ID: D2020-22 Background Making water-in-oil emulsions often requires high pressure, ultrasonication, or sensitive inversion techniques that may still only result in a semi-stable colloid. In addition to emulsion shelf life, these techniques have drawbacks, such as having high-energy consumption and narrow/sensitive production parameters, needing batch production processes, and being equipment intensive. Therefore, there is a need for a more efficient process to produce emulsions. Invention Description Researchers at the University of Toledo have developed a system to create an emu...Thu, 24 Jun 2021 12:11:35 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44086D2013-82http://utoledo.technologypublisher.com/technology/44025Project ID: D2013-82 Background Over 650,000 spine surgeries are performed annually in the United States, with the majority being decompressive laminectomies for spinal stenosis. Spinal stenosis is a narrowing of the spinal canal housing the spinal cord. It is generally caused by arthritis in the vertebral column and/or bulging of the intervertebral discs. The most common treatment for spinal stenosis involves a midline approach with a decompressive laminectomy to address the stenosis. Although highly effective in relieving pain, there is growing evidence and concern over the need for reope...Wed, 16 Jun 2021 11:27:14 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/44025D2021-08http://utoledo.technologypublisher.com/technology/43445Wed, 21 Apr 2021 11:34:53 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/43445D2017-15http://utoledo.technologypublisher.com/technology/43143Mon, 08 Mar 2021 08:33:31 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/43143D2021-04http://utoledo.technologypublisher.com/technology/43092Mon, 01 Mar 2021 09:10:43 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/43092D2021-02http://utoledo.technologypublisher.com/technology/42953Mon, 08 Feb 2021 09:00:58 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/42953D2019-35http://utoledo.technologypublisher.com/technology/42731Tue, 12 Jan 2021 07:10:22 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/42731D2020-37http://utoledo.technologypublisher.com/technology/42722Mon, 11 Jan 2021 13:19:25 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/42722D2019-45http://utoledo.technologypublisher.com/technology/42697Project ID D2019-45 Background Thyroid cancer is the most common endocrine cancer globally, and accounts for 3.4% of all new cancer cases in the US. Although several clinical guidelines to detect/manage thyroid nodules are available, a great deal of controversy still exists around the optimal approach for diagnosis. Approximately 20-30% of cytology results from thyroid fine-needle aspiration (FNA) fall into one of three indeterminate diagnostic categories. In recent years, a number of molecular and gene mutation diagnostic tests have been developed to diagnose the indeterminate thyroid nodule...Mon, 11 Jan 2021 12:33:28 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/42697D2019-34http://utoledo.technologypublisher.com/technology/42687Mon, 11 Jan 2021 07:20:50 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/42687D2020-04MP2http://utoledo.technologypublisher.com/technology/41477Project ID: D2020-04 Background: Detection of free radicals (ROS) is vital in maintaining food safety as the estimated economic damage caused by the impact on food safety is $7 billion per year in the US. The presence of ROS causes devastating effects on the food as it leads to oxidation of proteins, breakage of oligonucleotides, or irreparable altering of gene expression. The current state of the art for detecting free radicals include assay kits using colorimetric methods, metal oxidation methods, and electromagnetic spin resonance (ESR) or electro paramagnetic resonance (EPR), and these a...Tue, 08 Sep 2020 10:43:03 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41477D2020-04MP1http://utoledo.technologypublisher.com/technology/41476Project ID: D2020-04 Background: Owing to increased threat to the environment, the market for eco-friendly hydrogen fuel cell vehicle is expected to hit $42 billion by 2026. However, concerns over the degradation of the current fuel cell technology is one of the biggest shortcomings. The durability issue persists in the ion exchange membrane that affects the overall performance of the polymer electrolyte membrane (PEM) fuel cells. The chemical degradation of the fuel cell operation is primarily due to the reactive oxygen species (ROS) or free radicals of which the hydroxyl radicals are the m...Tue, 08 Sep 2020 10:35:30 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41476D2011-08http://utoledo.technologypublisher.com/technology/41219Thu, 06 Aug 2020 12:18:07 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41219D2020-04http://utoledo.technologypublisher.com/technology/41182Tue, 04 Aug 2020 07:40:24 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41182D2018-15http://utoledo.technologypublisher.com/technology/41151Thu, 30 Jul 2020 07:54:50 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41151ENG00204http://utoledo.technologypublisher.com/technology/41150Wed, 29 Jul 2020 11:53:29 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41150D2009-11http://utoledo.technologypublisher.com/technology/41149Wed, 29 Jul 2020 11:41:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41149D2019-40http://utoledo.technologypublisher.com/technology/41143Wed, 29 Jul 2020 08:33:22 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41143D2006-10http://utoledo.technologypublisher.com/technology/41129Mon, 27 Jul 2020 12:14:14 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41129D2019-08http://utoledo.technologypublisher.com/technology/41033Thu, 16 Jul 2020 12:55:46 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/41033D2019-32http://utoledo.technologypublisher.com/technology/39636 Project ID: D2019-32 Background: Breast cancer (BC) is a heterogeneous disease and is the second leading cause of death in women among the cancer mortalities. With the new estimates in 2019, 3 out of 10 women will develop BC in her lifetime and 1 in 7 will succumb to BC. Mortality in BC patients is mainly due to metastasis to the lungs, bone, and brain. Triple-negative breast cancer (TNBC) is a highly aggressive form of BC with increased risk of relapse, drug resistance, and metastases. CXCR4 has been identified to be one of the major chemokine receptors involved in breast cancer metastasis,...Wed, 22 Apr 2020 10:42:53 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/39636D2018-22http://utoledo.technologypublisher.com/technology/39140Wed, 11 Mar 2020 08:20:31 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/39140D2013-31http://utoledo.technologypublisher.com/technology/39131 Project ID: D2013-31 Novelty: Development of a novel electromagnetic polymer composite material for enhanced anti-fouling effects. Background: Biofouling (bacterial attachment to solid surfaces and colonization) is the main source of bacterial infection and poses potentially harmful impacts on human health. Medical devices, food packaging, and drinking water distribution systems are all susceptible to biofouling. For example, biofouling in an indwelling urinary tract catheter (IUTC) is the cause of 80% of urinary tract infections (UTI), the most common hospital associated infection. Control...Wed, 11 Mar 2020 06:10:40 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/39131D2009-89http://utoledo.technologypublisher.com/technology/39124 Project ID: D2009-89 Background Polymerization reactions are used in industry to make widely used products, such as polyolefins. There has been an interest in improving control over polymer tacticity and co-polymerization, leading to the development of Constrained Geometry Catalysts (CGCs). The CGCs form complexes with a pi-bonded moiety bridged to a donor group on a shared metal center. The angle formed results in a constrained geometry and an active catalyst for polymerization. CGCs are typically dianionic and made with group 3 and 4 metals, with a strong focus on titanium and zirconium....Tue, 10 Mar 2020 13:12:19 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/39124D2005-05http://utoledo.technologypublisher.com/technology/38371Thu, 30 Jan 2020 12:14:43 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/38371D2019-47http://utoledo.technologypublisher.com/technology/37217Wed, 20 Nov 2019 07:30:50 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/37217D2016-66http://utoledo.technologypublisher.com/technology/36687Wed, 16 Oct 2019 07:43:19 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/36687D2019-30http://utoledo.technologypublisher.com/technology/35520Mon, 19 Aug 2019 11:52:31 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/35520D2018-57http://utoledo.technologypublisher.com/technology/34662Mon, 24 Jun 2019 07:04:24 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/34662D2014-41http://utoledo.technologypublisher.com/technology/34532Thu, 13 Jun 2019 10:13:16 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/34532D2019-13http://utoledo.technologypublisher.com/technology/34298Thu, 16 May 2019 10:24:33 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/34298D2019-22http://utoledo.technologypublisher.com/technology/32652Tue, 14 May 2019 05:57:51 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/32652D2016-81http://utoledo.technologypublisher.com/technology/31915Wed, 03 Apr 2019 11:40:34 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/31915D2018-23http://utoledo.technologypublisher.com/technology/31856Tue, 26 Mar 2019 10:07:00 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/31856D2018-40http://utoledo.technologypublisher.com/technology/31649Mon, 11 Mar 2019 13:07:19 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/31649D2019-15http://utoledo.technologypublisher.com/technology/30028Tue, 04 Dec 2018 12:03:01 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/30028D2018-55http://utoledo.technologypublisher.com/technology/29037Wed, 17 Oct 2018 06:45:25 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/29037D2015-60http://utoledo.technologypublisher.com/technology/28517Mon, 20 Aug 2018 08:39:50 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/28517D2018-52http://utoledo.technologypublisher.com/technology/28296Wed, 25 Jul 2018 11:20:03 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/28296D2018-46http://utoledo.technologypublisher.com/technology/28267Tue, 24 Jul 2018 12:32:30 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/28267D2018-28http://utoledo.technologypublisher.com/technology/27641Wed, 02 May 2018 12:35:25 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27641D2018-27http://utoledo.technologypublisher.com/technology/27597Mon, 23 Apr 2018 12:58:09 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27597D2018-25http://utoledo.technologypublisher.com/technology/27595Mon, 23 Apr 2018 10:42:46 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27595D2018-36http://utoledo.technologypublisher.com/technology/27572Tue, 17 Apr 2018 11:56:27 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27572D2017-08http://utoledo.technologypublisher.com/technology/27551Mon, 16 Apr 2018 08:55:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27551D2018-33http://utoledo.technologypublisher.com/technology/27406Thu, 22 Mar 2018 09:36:04 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27406D2016-39http://utoledo.technologypublisher.com/technology/27299Tue, 13 Mar 2018 09:27:02 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27299D2016-72http://utoledo.technologypublisher.com/technology/27297Tue, 13 Mar 2018 08:53:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27297D2017-07http://utoledo.technologypublisher.com/technology/27237Mon, 05 Mar 2018 06:41:57 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/27237D2018-18http://utoledo.technologypublisher.com/technology/26968Thu, 25 Jan 2018 08:18:36 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26968D2018-03http://utoledo.technologypublisher.com/technology/26944Tue, 23 Jan 2018 05:41:38 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26944D2018-16http://utoledo.technologypublisher.com/technology/26940Mon, 22 Jan 2018 12:28:04 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26940D2014-08http://utoledo.technologypublisher.com/technology/26890Project ID: D2014-08Background Underwater adhesion has several potential medical, household and industrial applications. Generally, underwater adhesives have been prepared using methods that rely on in situ polymerization, covalent crosslinking, or the use of highly specialized biological or biomimetic polymers. Despite current strategies, many challenges have limited the yield and application of biomimetic adhesives including cost, inefficient recombinant protein production, complicated syntheses, the use of potentially harmful oxidants and the need for highly specialized polymer structures. ...Tue, 16 Jan 2018 12:56:18 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26890D2012-14http://utoledo.technologypublisher.com/technology/26847Wed, 10 Jan 2018 09:18:40 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26847D2018-08http://utoledo.technologypublisher.com/technology/26737Mon, 18 Dec 2017 05:51:48 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26737D2015-17http://utoledo.technologypublisher.com/technology/26637Wed, 29 Nov 2017 10:55:28 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26637D2014-05http://utoledo.technologypublisher.com/technology/26613Wed, 22 Nov 2017 10:39:58 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26613D2017-06http://utoledo.technologypublisher.com/technology/26349Mon, 02 Oct 2017 08:10:45 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26349D2017-09http://utoledo.technologypublisher.com/technology/26348Mon, 02 Oct 2017 07:53:41 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/26348D2016-03http://utoledo.technologypublisher.com/technology/23722 p { margin-top: 0px;margin-bottom: 0px;line-height: 1.15; } body { font-family: 'Verdana';font-style: Normal;font-weight: normal;font-size: 16px; } .Normal { telerik-style-type: paragraph;telerik-style-name: Normal;border-collapse: collapse; } .TableNormal { telerik-style-type: table;telerik-style-name: TableNormal;border-collapse: collapse; } .NormalWeb { telerik-style-type: paragraph;telerik-style-name: NormalWeb;margin-top: 6.66px;margin-bottom: 6.66px;border-collapse: collapse; } Wed, 21 Dec 2016 09:26:18 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/23722D2016-01http://utoledo.technologypublisher.com/technology/23721Wed, 21 Dec 2016 09:17:50 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/23721D2015-43http://utoledo.technologypublisher.com/technology/23505Wed, 09 Nov 2016 07:45:01 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/23505D1995-12ehttp://utoledo.technologypublisher.com/technology/22983Mon, 10 Oct 2016 07:23:02 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22983D2015-13http://utoledo.technologypublisher.com/technology/22880Project ID: D2015-13Background Truncated patterns of oligosaccharides on the surfaces of cancer cells can serve as biomarkers that help to distinguish tumor cells from healthy ones. These are known as tumor-associated carbohydrate antigens (TACAs). A significant portion of cancer antigens have been identified as TACAs. Thus TACAs can be exploited for cancer immunotherapy. However, the immunological nature of carbohydrate epitopes renders TACAs unable to elicit strong T cell-dependent immune responses. TACAs have also failed to induce class switching for high affinity IgG antibodies and memory ...Wed, 21 Sep 2016 10:24:31 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22880D2016-44fhttp://utoledo.technologypublisher.com/technology/22763Tue, 30 Aug 2016 06:27:14 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22763D2016-44ahttp://utoledo.technologypublisher.com/technology/22762Tue, 30 Aug 2016 06:22:23 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22762D2016-44bhttp://utoledo.technologypublisher.com/technology/22761Tue, 30 Aug 2016 06:19:47 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22761D2015-58http://utoledo.technologypublisher.com/technology/22434Wed, 13 Jul 2016 06:36:28 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22434D2016-53http://utoledo.technologypublisher.com/technology/22402Wed, 06 Jul 2016 11:40:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/22402D2016-29http://utoledo.technologypublisher.com/technology/21699Thu, 07 Apr 2016 08:57:10 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21699D2016-48http://utoledo.technologypublisher.com/technology/21692Wed, 06 Apr 2016 12:50:02 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21692D2016-49http://utoledo.technologypublisher.com/technology/21691Wed, 06 Apr 2016 12:34:39 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21691D2016-41http://utoledo.technologypublisher.com/technology/21393Wed, 10 Feb 2016 12:40:29 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/21393D2015-27http://utoledo.technologypublisher.com/technology/19797Wed, 17 Jun 2015 11:37:27 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19797D2013-69http://utoledo.technologypublisher.com/technology/19796Wed, 17 Jun 2015 11:37:25 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19796D2014-15http://utoledo.technologypublisher.com/technology/19794Wed, 17 Jun 2015 11:06:24 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19794D1995-23http://utoledo.technologypublisher.com/technology/19703Tue, 02 Jun 2015 12:20:03 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/19703D2013-04http://utoledo.technologypublisher.com/technology/18210Project ID: D2013-04Background Lung cancer is the leading cause of cancer deaths in the United States. More than 80% of the lung cancer deaths belong to non-small cell lung cancer (NSCLC). The 5-year survival rate of patients with NSCLC is about 16% with current treatments including surgery, radiation and other classic chemotherapeutic agents and targeted therapies. It is thus essential to pursue novel ways to treat this disease more effectively. Invention DescriptionResearchers from The University of Toledo have developed a new class of small drug-like molecules with remarkable selectivity fo...Tue, 03 Feb 2015 10:22:31 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/18210D2014-33http://utoledo.technologypublisher.com/technology/15747Project ID: D2014-33Novelty: Small drug like molecules that inhibits DNA repair factors for cisplatin (and other platinum based drugs) resistance towards solid tumors, thereby increasing cisplatin cytotoxicity and efficacy. Value proposition: One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer cells. Although increased DNA repair has been shown to be a major mechanism of cancer drug resistance, not much was done until recently to address this challenge. The researchers at The University of Toledo have discovered small drug like molecules th...Tue, 19 Aug 2014 08:26:50 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15747D2013-70http://utoledo.technologypublisher.com/technology/15529Tue, 15 Jul 2014 12:38:28 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15529D2013-88http://utoledo.technologypublisher.com/technology/15239Wed, 21 May 2014 08:02:05 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/15239D2012-18http://utoledo.technologypublisher.com/technology/14995 Project: D2012-18 Strains: EST3Tg/C57BL6 and EST3Tg/Apoe-/- Type: Humanized transgenic mouse Background: In the U.S., atherosclerosis, hypertension and stroke are the major causes of death due to cardiovascular disease and remain most frequent vascular complications of metabolic diseases such as diabetes, obesity and metabolic syndrome. A common signature of the associated vascular pathology is the presence of a dysfunctional endothelium, endothelial inflammation and/or changes in endothelial integrity. Research over the last fifteen years led to identification of members of the Transie...Mon, 07 Apr 2014 12:36:21 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/14995D1995-15bhttp://utoledo.technologypublisher.com/technology/11662Wed, 19 Dec 2012 10:24:39 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11662D1995-12dhttp://utoledo.technologypublisher.com/technology/11661Wed, 19 Dec 2012 10:24:37 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11661D2011-29http://utoledo.technologypublisher.com/technology/11376Wed, 24 Oct 2012 11:36:58 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11376D2011-63http://utoledo.technologypublisher.com/technology/11365Tue, 23 Oct 2012 07:48:03 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11365D1995-19ahttp://utoledo.technologypublisher.com/technology/11345Tue, 16 Oct 2012 11:56:38 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11345D1995-19bhttp://utoledo.technologypublisher.com/technology/11344Tue, 16 Oct 2012 11:56:37 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11344D1995-20http://utoledo.technologypublisher.com/technology/11343Tue, 16 Oct 2012 11:56:33 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11343D1995-21http://utoledo.technologypublisher.com/technology/11342Tue, 16 Oct 2012 11:56:32 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11342D1995-18ahttp://utoledo.technologypublisher.com/technology/11341Tue, 16 Oct 2012 11:56:29 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11341D1995-18bhttp://utoledo.technologypublisher.com/technology/11340Tue, 16 Oct 2012 11:56:28 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11340D1995-16bhttp://utoledo.technologypublisher.com/technology/11336Tue, 16 Oct 2012 09:01:19 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11336D1995-17bhttp://utoledo.technologypublisher.com/technology/11335Tue, 16 Oct 2012 09:01:18 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11335D1995-12chttp://utoledo.technologypublisher.com/technology/11333Tue, 16 Oct 2012 09:01:17 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11333D1995-17ahttp://utoledo.technologypublisher.com/technology/11332Tue, 16 Oct 2012 09:01:16 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11332D1995-13ahttp://utoledo.technologypublisher.com/technology/11331Tue, 16 Oct 2012 09:01:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11331D1995-12bhttp://utoledo.technologypublisher.com/technology/11330Tue, 16 Oct 2012 09:01:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11330D1995-12ahttp://utoledo.technologypublisher.com/technology/11329Tue, 16 Oct 2012 09:01:14 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11329D1995-13bhttp://utoledo.technologypublisher.com/technology/11327Tue, 16 Oct 2012 09:01:11 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11327D1995-16ahttp://utoledo.technologypublisher.com/technology/11326Tue, 16 Oct 2012 09:01:11 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11326D1995-14http://utoledo.technologypublisher.com/technology/11325Tue, 16 Oct 2012 09:01:10 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11325D1995-15http://utoledo.technologypublisher.com/technology/11323Tue, 16 Oct 2012 09:01:08 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11323D1995-11http://utoledo.technologypublisher.com/technology/11319Tue, 16 Oct 2012 05:55:15 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11319D2009-27http://utoledo.technologypublisher.com/technology/11194Thu, 27 Sep 2012 07:40:49 GMTjackie.wilkinson@utoledo.eduhttp://utoledo.technologypublisher.com/technology/11194