Search Results - Long+Bone%2fJoint+Repair

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Novel Therapeutics for Osteoporosis, Osteoarthritis and Other Musculoskeletal Diseases

Project ID: D2013-47 Novelty: Three categories of drug-like molecules that have been identified to promote bone and cartilage formation from stem cells. Value Proposition: Osteoporosis and Osteoarthritis are complex musculoskeletal diseases that are prevalent in the aging population. Worldwide,...

Analogs of peroxisome proliferator activated receptor (PPAR) agonists, and methods of using the same

Osteoporosis is a silent disease of bones that affects tens of millions of people over the age of 50 with direct medical costs of over $31 billion yearly due to injuries from falls. With the aging population of the US there is a serious need for effective treatments to combat bone loss. There are currently no drugs developed to raise bone mass to normal...

Osteoanabolism by 14-3-3zeta

Project ID: D2021-48 Background Bone loss is one of the common symptoms associated with normal aging and pathologies. An increased bone mass loss and mineral density are the primary reason for osteoporosis, arthritis, fractures, etc. Together it affects millions of individuals in the US alone. While several drugs targeting the prevention of bone...

Thermoresponsive Injectable Microparticles-Gel Composites with Low Dose of Recombinant BMP-9 and VEGF for Bone Repair

Bone repair remains a major clinical need because autograft and allograft approaches can be limited by donor-site morbidity, pain, resorption, disease-transmission risk, and immune rejection. Tissue-engineered alternatives seek to combine osteoconductive scaffolds, osteoinductive factors, and regenerative cells, but many scaffold systems require invasive...

Fixation and Reconstruction System for Ankle Fractures

Project ID: D2018-27Background Syndesmotic Ankle fractures are common, and sometimes challenging to treat clinically. These fractures are a common source of substantial patient morbidity. It is estimated that about 290,000 people suffer syndesmotic ankle injuries every year in the United States. Devices that are currently used to treat these ankle...

External Locking Fixation for Tibia Fractures

Project ID: D2018-25 Extra-articular tibia fractures which include proximal tibia, diaphysis and distal tibia fractures are often associated with many serious complications and result in disability. Current treatment methods include the use of an intramedullary rod, an internal locking/unlocking plate, and an external fixator. However, these treatment...