Biosensor Device to Detect Infection in Real Time


Project ID: D2013-32

Invention novelty: Sensor capable of rapid differentiation between viral and bacterial infections (in vivo or in situ). If bacterial, provides capability to segment into either Gram-positive or Gram-negative bacteria.  

Value proposition:

·       Receptor component can be configured to have different sensing elements that can be clustered or arrayed for use in detection of multiple target analytes including antibody, antibody fragment, aptamer, or enzyme.

·       Analytes to be detected include biomolecules such as bacteria, viruses, proteins, nucleic acids, microRNAs, carbohydrates, microRNAs, and other molecules that may indicate the presence of an infection, a cancer, or toxin.

·       Target analytes that can be detected using the biosensor device described herein can be present in a sample that comprises tissue or fluid of a living organism. Non-limiting examples of tissue include soft tissue, hard tissue, skin, surface tissue, outer tissue, internal tissue, a membrane, fetal tissue and endothelial tissue.

·       Biosensor device can be configured to compensate for any noise at the time of the sampling and for use on small (e.g., nanoscale) samples.

Applications: Device can be used for medical, dental, veterinary, or environmental applications and may be adapted and incorporated into any of several suitable medical instruments or surgical tools, including on the flexible tip of an elongated medical instrument. Detects analytes in living or non-living samples including surgical incisions, open or closed wounds, organ, skin, membranes, in situ fluids such as blood, urine, and the like. In addition, the sample can be food sources including grains, beverages, milk and dairy products, fish, shellfish, eggs, commercially prepared and/or perishable foods for animal or human consumption (e.g., ground meat, salads, and the like). The sample can also be food tissue including fruit, edible plants, vegetables, roots, soy products, dead animal tissue, meat, fish and eggs, where the presence of the target analyte indicates spoilage. The sample can also be detected in external environments including soil, water ways, sludge, commercial effluent.

IP Status: PCT Patent Application Serial No. PCT/US14/023126

Patent Information:
For Information, Contact:
Katherine Pollard
Licensing Associate
The University of Toledo
Anand Agarwal
Vijay Goel
Dong Shik Kim
Do Young Yoon
Boren Lin
Hamid Feyzizarnagh