Antibacterial Surfactant and Microgel Mixtures Prepared via Polyelectrolyte Complexation, Ionic or Covalent Crosslinking

Description:

Background

Antibacterial surfactant formulations are typically prepared using cationic surfactants (alkyltrimethylammonium salts). These surfactants, however, are toxic; consequently, their use in cleaning formulations raises environmental concerns. Triclosan and triclocarbon are antimicrobials used in many products, such as soaps and other personal care products. With the consensus of more than 200 scientists and health care professionals, the Florence Statement was issued to discuss the effects of these products on our environment. Triclosan and triclocarbon are endocrine disruptors, have detrimental effects on aquatic plants and animals, and persist in the environment as toxic and carcinogenic compounds, such as dioxins or chlorinated anilines. They have been found in human blood, urine, and breast milk, and many matrices around the world. The FDA has already restricted use of both antimicrobials, calling for novel options that are safer for the environment.
 

Description

The disclosed invention is a surfactant mixture with biocompatible antibacterial microgels that are prepared through polyelectrolyte complexation, ionic or covalent crosslinking. These bio-based formulations exhibit high antimicrobial activity, thus allowing for the use of low concentrations of the active agents to obtain rapid killing of large numbers of microbes upon contact and are especially effective against the disinfectant-resistant pathogen, Pseudomonas aeruginosa.

 

Description

The disclosed invention is a surfactant mixture with biocompatible antibacterial microgels that are prepared through polyelectrolyte complexation, ionic or covalent crosslinking. These bio-based formulations exhibit high antimicrobial activity, thus allowing for the use of low concentrations of the active agents to obtain rapid killing of large numbers of microbes upon contact and are especially effective against the disinfectant-resistant pathogen, Pseudomonas aeruginosa.

 

Application

  • Household, industrial, and medical antibacterial cleaning products, including laundry detergents, dishwasher soaps, fabric care formulations, and person care products

 

Advantages

  • Effective against disinfectant-resistant Pseudomonas aeruginosa
  • Formulation offers an attractive alternative to toxic cationic surfactants and triclosan which degrades into dioxin -- a suspected allergen and carcinogen precursor
  • Attractive alternatives to toxic antibacterial formulations
     
  • Non-toxic surfactant cleans and bio-based microgels disinfect
  • Good formulation stability, excellent solubilization and detergency properties
  • Active ingredient can be bio-based and biodegradable

IP Status:                           Patents: US 9,788,541 and 10,010,078

 

Publications:     

Patent Information:
Category(s):
Materials
Polymers
For Information, Contact:
Katherine Pollard
Licensing Associate
The University of Toledo
419-530-6228
katherine.pollard@utoledo.edu
Inventors:
Yakov Lapitsky
Youngwoo Seo
Keywords:
Antibacterial
Antimicrobial
Cleaning
Disinfectant
Surfactant