Novel compounds and methods for exosome production

Description:

Project ID:  D2017-25

 

Background

Exosomes are vesicles in the range of 30 to 120nm, which are released from mammalian cells when multi-vesicular endosomes fuse with the plasma membrane. In recent times, exosomes have been implicated in cancer. Mounting evidence suggests that exosomes play an important role in mediating intercellular communication within the tumor microenvironment and promoting cancer invasion and metastasis. Exosomes have also attracted major attention as potential drug and therapeutic nano-carriers. It would, therefore, be very important to develop compounds that are able to stimulate or inhibit the production of exosomes without affecting cell growth or viability. 

 

Invention Description

Researchers at the University of Toledo, led by Dr. William Maltese, have developed a novel indole-based chalcone, a distinct triazine-based compound and corresponding methods to induce and harvest exosomes from cells. 

 

Applications

•       Exosomes may be used as drug and RNA therapeutic delivery vehicles

•       The exosomes may be used as diagnostics to track tumor occurrence and progression

Advantages

•       Cell proliferation and viability are not impaired by the compounds.

•       Compared to controls the characteristics of exosomes from treated cells showed no significant difference.

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IP Status:       Patent pending, WO 2018-151937

 

Publications:       Li Z et al., Vacuole-inducing compounds that disrupt endolysosomal trafficking stimulate production of exosomes by glioblastoma cells. Molecular & Cellular Biochemistry, 2017, 11010-11017

Patent Information:
For Information, Contact:
Katherine Pollard
Licensing Associate
The University of Toledo
419-530-6228
katherine.pollard@utoledo.edu
Inventors:
William Maltese
Paul Erhardt
Zehui (Lesley) Li
Christopher Trabbic
Keywords:
Cancer
Exosome
Vacuole
Vesicle