Injectable Biodegradable Bone Matrix for Multiple Myeloma Lesion Augmentation and Osteoporosis

Description:

Project ID: D2013-62

Invention Description and Novelty: Unique technology targets both ends of the bone remodeling process by introducing therapies to suppress osteoporosis and restore bone formation in the case of multiple myeloma and other cancer-induced bone diseases.  

Value proposition:

·       Unique injectable bone filler composition sets into a hardened mass comprised of a cement and other structures capable of releasing therapeutic agents or cells;

·       Composition exhibits mechanical and handling properties comparable to PMMA, and is osteoconductive, biodegradable, and less exothermic than PMMA;

·       Stabilizes fractured vertebrae and supports or induces bone regeneration;

·       Data shows that the method blocks bone resorption;

·       Provides reinforced cement scaffold, improving its handling properties and increasing its drug delivery capabilities;

·       Composition exhibits a synergistic effect to protect bone tissue from multiple myeloma or other disease-induced damage;

·       Therapeutic agents incorporated into the composition can also target myeloma cells to induce cell death or inhibit tumor progress, being administered directly to the location of the treatment instead of via circulation;

·       Suitable therapeutic agents for use in bone filler material include, but are not limited to: anti-osteoclastic agents, peptides, proteins, nucleic acids, antibiotics, antimicrobials, antifungals, antiseptics, antivirals, antiparasitics, antiprotozoals, wound healing agents, local anaesthetics, mucolytics, anti-allergies, antioxidants, vitamins, steroidal and non-steroidal anti-inflammatory agents, antihistamines, chemotherapeutic agents, tumor growth inhibitory agents, cytostatics, and combinations thereof.

·       Various additives may be included in the bone filler composition to adjust its properties;

·       Compositions and methods described herein could be embodied as parts of a kit or kits

Applications include but are not limited to bone augmentation surgery to treat cancer-induced bone disease.

IP Status: PCT Patent Application No. PCT/US14/026,099

Patent Information:
For Information, Contact:
Stephen Snider
AVP Tech Transfer
The University of Toledo
419 530 6225
Stephen.Snider@utoledo.edu
Inventors:
Vijay Goel
Dong-Shik Kim
Sarit Bhaduri
Boren Lin
Anand Agarwal
Keywords:
Augmentation
Bone
Cement
Multiple Myeloma
Osteoporosis