Search Results - stroke

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Treatment of Ischemic Stroke with ROS-Sensitive Nitric Oxide Synthase Inhibitors
Project ID: D2018-11Background Nearly 800,000 people in the United States suffer a stroke every year, with about 87% of the strokes being classified as ischemic. Ischemic stroke is caused by blockage of blood flow to the brain, which results in neuronal and glial hypoxia and, subsequently, inflammatory and free radical-mediated cell death. Reactive...
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Furoxans as Novel Therapeutics for Neurodegenerative Disorders
Project ID: D2017-15Invention Description:Nitric oxide (NO) signaling is essential for brain activity and normal neuronal function. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetics, such as nitrates, have been implicated for use against a variety of neurological disorders, in...