Search Results - steven sucheck

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Enhanced Immunogenicity Vaccine Development Platform
Project ID: D2012-14BackgroundExtensive research is being carried out globally to develop vaccines for the treatment of different types of infections and diseases. However, improved immunogenicity and efficient delivery of antigens to the antigen producing cells (APCs) via these vaccines is still a challenge. Also, it is very costly and time consum...
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Immunostimulatory adjuvant molecules and antibody recruiting molecule-containing lipopeptide vaccines
Project ID: D2017-06Background Protein conjugate vaccines have limitations due to the innate immunogenicity of carrier proteins that can suppress the response against associated antigens. Thus, the development of fully synthetic vaccines have been under intense investigation in the last decade in immunotherapy. A typical fully synthetic vaccine in...
Anti-Infective Antibacterial Agents against Mycobacterium Tuberculosis and other Mycobacterium Species
Project ID: D2016-53IP Status: PCT patent application #PCT/US17/028782Invention Description and Novelty: New compound represents useful antimicrobial agents effective against human and veterinary pathogens, particularly acid-fast organisms such as Mycobacterium tuberculosis and shows improved efficacy and activity well below toxicity to human monoc...
Solid-phase Synthesis of Difficult Peptides and Peptide Conjugates
Project ID: D2012-01Background: There is a need in the field of peptide synthesis and peptide conjugate synthesis for chemistry capable of linking sterically demanding amino acids to form difficult peptides. These difficult peptide sequences result when incomplete peptide bond formation and/or deprotection reactions occur at various stages in soli...