Search Results - ronald+viola

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Species-specific inhibitors of methionine adenosyltransferase (MAT)

Project ID: TECH2023-31 Background Drug resistance, especially to antibiotics and other antimicrobials, is a huge and growing problem. Some bacteria already have untreatable strains, and other microbes have never had good drug options. Broad-spectrum antibiotics have substantial side effects, including microbiome disruption. Cryptosporidium parvum...

Potent Compounds for the Treatment of Canavan Disease & Cancers

Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of Canavan disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes aspartate...

Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms

Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...