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Advancement in Platinum Based Cancer Therapeutics

Project ID: D2013-02 Background One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer cells. Although increased DNA repair has been shown to be a major mechanism of cancer drug resistance, not much was done until recently to address this challenge. The researchers at The University of Toledo have...

Advancement in Platinum Based Cancer Therapeutics

Project ID: D2014-33Novelty: Small drug like molecules that inhibits DNA repair factors for cisplatin (and other platinum based drugs) resistance towards solid tumors, thereby increasing cisplatin cytotoxicity and efficacy. Value proposition: One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer cells....