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Potent Compounds for the Treatment of Canavan Disease & Cancers

Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of Canavan disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes aspartate...

Muscarinic Agonists for the Treatment of Autism Spectrum Disorder

Project ID: D2011-54Background Autism Spectrum Disorder (ASD) describes a group of developmental disorders that is often characterized by persistent repetitive and restrictive behaviors and deficits in social communication that, overall, affect the ability of the individual to functional normally in a social setting. Although early treatment and care...