Search Results - liyanaaratchige tillekeratne

4 Results Sort By:
A new class of HDAC inhibitors with a new metal-binding group
Project ID: D2018-08Background Cancer is group of diseases characterized by uncontrolled growth of abnormal cells. Selectivity towards cancer cells has been challenging, resulting in treatment options with severe side effects. Histone deacetylases (HDAC) are highly expressed in cancer cells and have been investigated for cancer drug development. O...
Novel HDAC Inhibitors as Anti-Cancer Agents
Project: D2014-49 Background: Cancer remains the second most common cause of death, accounting for nearly 1 out of every 4 deaths in the United States. American Chemical Society has estimated diagnosis of more than 1.6 million new cancer cases and deaths of more than 500,000 cancer patients in the US in the year 2014 alone. A promising new anticanc...
Small Drug-Like Molecules as Anticancer Agents Selective for Cancer Stem Cells
Project ID: D2013-04Novelty: A new class of anticancer agents which are highly selective for mesenchymal cancer cells with stem cell like properties.Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the same time, tumors are heterogeneous and curre...
Novel Epothilone Analogues as Antileukemia Agents and Method Thereof
Project ID: PHR00107 Novelty: Conformationally restrained novel epothilone analogue exhibiting strong and selective growth inhibitory effect on leukemia cell lines. Background: Epothilones have been reported to exhibit potent anticancer activity and a number of epothilone analogs have entered clinical evaluation in humans (in addition to Epo B),...