Search Results - juan jaume

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CAR T Preventive/Therapeutic approach for Type 1 Diabetes
Project ID: D2019-07Background Type 1 diabetes (T1D) is an autoimmune disease with no cure and is currently treated with daily insulin injections. Cytotoxic T cells have been shown to contribute to the progression of the disease, and can be down regulated to control the attack on insulin-producing beta cells. Regulatory T cells (Tregs) have been in...
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model o...