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Potent Compounds for the Treatment of Canavan Disease & Cancers

Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of Canavan disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes aspartate...

Use of Small Molecule Inhibitors as Anti-Thrombotic Agents

ont-size:12px">Project ID: D2016-03 Background Various ailments, including systemic lupus erythematosus (SLE), rheumatoid arthritis and certain cancers can cause a person to suffer a thrombotic event. There are various therapies currently used for treating pro-thrombotic platelets, including molecules that can be divided into families based on mechanism...

Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms

Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...