Search Results - f.+charles+brunicardi

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Micropatterned Silicone Oxygenating Dressing For Chronic Wounds

Project ID: D2018-09Background Wound healing requires oxygen, moisture, and pressure offloading. It is difficult to simultaneously obtain these conditions because oxygen has a low diffusivity in water. Hyperbaric oxygen therapy (HBOT) is an approved treatment which uses a pressurized chamber to increase oxygen absorption. However, patients must be ambulatory...

Smart Exosomes Enable Active Pdac Targeting and Evading Mononuclear Phagocycotic System

Project ID: D2021-13 Background Patients affected by pancreatic ductal adenocarcinoma (PDAC), an aggressive type of cancer, have a 5-year survival rate of 9%, the lowest of any cancer in the US. Therapies for pancreatic cancer are largely hindered by the lack of an effective delivery system. Exosomes are emerging as promising nanocarriers for genes...

Targeting LASP1, eIF4A1, eIF4B, and CXC4 with Modulators for treating cancer

Project ID: D2019-32 Background: Breast cancer (BC) is a heterogeneous disease and is the second leading cause of death in women among the cancer mortalities. With the new estimates in 2019, 3 out of 10 women will develop BC in her lifetime and 1 in 7 will succumb to BC. Mortality in BC patients is mainly due to metastasis to the lungs, bone, and brain....