Search Results - drug-resistance

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Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms
Project ID: D2018-15 Background Most of current cancer therapy employs drugs that act through apoptotic signaling pathways. However, cancer cells often acquire mutations that can diminish apoptosis and lead to chemo-resistance when coupled with increased capacity for drug efflux and DNA repair. This results in chemotherapeutic failure especially...
Diagnostic and therapeutic biomarkers in human cancers
Project ID D2020-01Background IQGAP is a regulatory scaffold protein that organizes actin and microtubule cytoskeleton to regulate cell movement, division, and adhesion. It is an oncoprotein that can transduce signals emanating from surface receptors to the nucleus to control gene expression. IQGAP1 protein is regulated by addition or removal of phosphate...
Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms
Project ID: D2015-58Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel mechanism...