Search Results - drug-resistance

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Ferroptosis-HDAC Inhibitor Hybrids for treating cancer

Project ID: D2022-16 Background Many cancer treatments target cells and induce apoptosis, a cell death mechanism. Due to genetic instability, tumors become more heterogeneous leading to cells that avert molecular signatures that are targeted by the cancer drugs. Drug resistance remains a major impediment to the success of a cancer treatment. Combinatorial...

Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms

Project ID: D2018-15 Background Most current cancer therapies rely on agents that trigger apoptotic (programmed) cell-death pathways. During treatment, tumors can acquire mutations that diminish apoptotic responses and become chemoresistant, often accompanied by increased drug efflux and enhanced DNA repair. This resistance contributes to therapeutic...

Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms

Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...