Search Results - chandrabose+karthikeyan

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Antiproliferative necroptosis inducers or autophagy inhibitors or a combination thereof

Project ID: D2018-45 Breast cancer is the leading cause of cancer-related deaths in women worldwide, and triple negative breast cancer (TNBC) accounts for approximately 15-20% of these cancers. TNBC tumors do not express three key therapeutically relevant cell-surface receptors: estrogen receptor (ER), progesterone receptor (PR), and overexpression...

Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms

Project ID: D2018-15 Most current cancer therapies rely on agents that trigger apoptotic (programmed) cell-death pathways. During treatment, tumors can acquire mutations that diminish apoptotic responses and become chemoresistant, often accompanied by increased drug efflux and enhanced DNA repair. This resistance contributes to therapeutic failure, particularly...