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Potent Compounds for the Treatment of
Canavan
Disease & Cancers
Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of
Canavan
disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes aspartate...