Search Results - blood-brain+barrier

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Use of fluorescent ANTS to examine the BBB-permeability of polysaccharide

Project ID: D2015-27Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof.Applications: Compositions comprising midi and/or mini-GAGR have been shown to be useful for treatment of neurodegenerative...

Novel agents and methods for treating neurodegenerative disorders

Project ID: D2013-69 Midi-GAGR has several desired properties (neurotrophic, anti-oxidant, non-cytotoxic, anti-inflammatory, and BBB-permeable) for treatment of neurodegenerative diseases. Such materials have been shown to cross the blood-brain barrier, reduce the degeneration of cortical, peripheral, and dopaminergic nerve cells under pathogenic...