Search Results - amit+tiwari

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Antiproliferative necroptosis inducers or autophagy inhibitors or a combination thereof

Background Breast cancer is the leading cause of cancer-related deaths in women worldwide, and triple negative breast cancer (TNBC) accounts for approximately 15-20% of these cancers. TNBC tumors do not express three key therapeutically relevant cell-surface receptors: estrogen receptor (ER), progesterone receptor (PR), and overexpression of the...

Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms

Project ID: D2018-15 Background Most current cancer therapies rely on agents that trigger apoptotic (programmed) cell-death pathways. During treatment, tumors can acquire mutations that diminish apoptotic responses and become chemoresistant, often accompanied by increased drug efflux and enhanced DNA repair. This resistance contributes to therapeutic...

Targeting LASP1, eIF4A1, eIF4B, and CXC4 with Modulators for treating cancer

Project ID: D2019-32 Background: Breast cancer (BC) is a heterogeneous disease and is the second leading cause of death in women among the cancer mortalities. With the new estimates in 2019, 3 out of 10 women will develop BC in her lifetime and 1 in 7 will succumb to BC. Mortality in BC patients is mainly due to metastasis to the lungs, bone, and brain....