Search Results - alzheimer%27s

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Furoxans as Novel Therapeutics for Neurodegenerative Disorders

Project ID: D2017-15 Background Nitric oxide (NO) signaling plays a major role in brain activity and normal function of neurons. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetic, such as nitrates, have been used against a variety of neurological disorders. This is due to the...

Novel Compounds in Treating Autophagy-Related Pathologies

Project IDs: D2015-09 and D2016-81 Background: Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy...