Search Results - Therapeutics

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Magnetic Ionic Liquids Based Extraction and Purification of Nucleic Acids
Project ID # D2014-41Background:With a market of $3 billion in 2018 growing at a CAGR of 9.6 %, the nucleic acid isolation and extraction is one of the complex achievements in modern science. The analysis of deoxyribonucleic acid (DNA) plays a central role in a variety of applications such as determining microbial diversity in environmental samples...
Novel compound in treating autophagy-related pathologies
Project IDs: D2015-09 and D2016-81Background:Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autoph...
Potent Compounds for the Treatment of Canavan Disease & Cancers
Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of Canavan disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes a...
Therapeutic and Prophylactic for Arthritis
Project ID: D2019-15Background Rheumatoid Arthritis (RA) is an autoimmune disease that causes swelling of the joints. Treatments are limited to anti-inflammatories, DMARDs, corticosteroids or biologics. Genetic research has identified several genetic factors that determine susceptibility to developing RA. However, there are no prophylactics or the...
1,3-Butanediol as a therapeutic for kidney disease
Project ID: D2018-47Background Approximately 33 million Americans have kidney disease and over the last decade, the rate of chronic kidney disease has risen more than 25%. Kidney disease can cause additional complications including high blood pressure. For example, 80%-90% of CKD patients have high blood pressure at some point during their time wi...
Treatment of Ischemic Stroke with ROS-Sensitive Nitric Oxide Synthase Inhibitors
Project ID: D2018-11Background Nearly 800,000 people in the United States suffer a stroke every year, with about 87% of the strokes being classified as ischemic. Ischemic stroke is caused by blockage of blood flow to the brain, which results in neuronal and glial hypoxia and, subsequently, inflammatory and free radical-mediated cell death. Reactive...
Enhanced Immunogenicity Vaccine Development Platform
Project ID: D2012-14BackgroundExtensive research is being carried out globally to develop vaccines for the treatment of different types of infections and diseases. However, improved immunogenicity and efficient delivery of antigens to the antigen producing cells (APCs) via these vaccines is still a challenge. Also, it is very costly and time consum...
A new class of HDAC inhibitors with a new metal-binding group
Project ID: D2018-08Background Cancer is group of diseases characterized by uncontrolled growth of abnormal cells. Selectivity towards cancer cells has been challenging, resulting in treatment options with severe side effects. Histone deacetylases (HDAC) are highly expressed in cancer cells and have been investigated for cancer drug development. O...
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Immunostimulatory adjuvant molecules and antibody recruiting molecule-containing lipopeptide vaccines
Project ID: D2017-06Background Protein conjugate vaccines have limitations due to the innate immunogenicity of carrier proteins that can suppress the response against associated antigens. Thus, the development of fully synthetic vaccines have been under intense investigation in the last decade in immunotherapy. A typical fully synthetic vaccine in...
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