Search Results - Therapeutics

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Therapeutic and Prophylactic for Arthritis
Project ID: D2019-15Background Rheumatoid Arthritis (RA) is an autoimmune disease that causes swelling of the joints. Treatments are limited to anti-inflammatories, DMARDs, corticosteroids or biologics. Genetic research has identified several genetic factors that determine susceptibility to developing RA. However, there are no prophylactics or the...
Novel compounds and methods for exosome production
Project ID: D2017-25Background Exosomes are vesicles in the range of 30 to 120nm, which are released from mammalian cells when multi-vesicular endosomes fuse with the plasma membrane. In recent times, exosomes have been implicated in cancer. Mounting evidence suggests that exosomes play an important role in mediating intercellular communication wi...
1,3-Butanediol as a therapeutic for salt-sensitive hypertension
Project ID: D2018-47Background In many populations, salt intake is greater than the recommended 3.75 grams per day.Excess salt consumption can lead to cardiovascular, renal, and liver problems, including high blood pressure. Exercise can naturally decrease hypertension, but can be difficult for some patients to incorporate into their life. Current...
Treatment of Ischemic Stroke with ROS-Sensitive Nitric Oxide Synthase Inhibitors
Project ID: D2018-11Background Nearly 800,000 people in the United States suffer a stroke every year, with about 87% of the strokes being classified as ischemic. Ischemic stroke is caused by blockage of blood flow to the brain, which results in neuronal and glial hypoxia and, subsequently, inflammatory and free radical-mediated cell death. Reactive...
Enhanced Immunogenicity Vaccine Development Platform
Project ID: D2012-14BackgroundExtensive research is being carried out globally to develop vaccines for the treatment of different types of infections and diseases. However, improved immunogenicity and efficient delivery of antigens to the antigen producing cells (APCs) via these vaccines is still a challenge. Also, it is very costly and time consum...
A new class of HDAC inhibitors with a new metal-binding group
Project ID: D2018-08Background Cancer is group of diseases characterized by uncontrolled growth of abnormal cells. Selectivity towards cancer cells has been challenging, resulting in treatment options with severe side effects. Histone deacetylases (HDAC) are highly expressed in cancer cells and have been investigated for cancer drug development. O...
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Immunostimulatory adjuvant molecules and antibody recruiting molecule-containing lipopeptide vaccines
Project ID: D2017-06Background Protein conjugate vaccines have limitations due to the innate immunogenicity of carrier proteins that can suppress the response against associated antigens. Thus, the development of fully synthetic vaccines have been under intense investigation in the last decade in immunotherapy. A typical fully synthetic vaccine in...
Concurrent Delivery of Interstitial Thermobrachytherapy in Cancer Treatment
Project ID: D2017-09Background Brachytherapy is a minimally invasive treatment that allows a dose of radiation to be delivered to a defined treatment area using a radioactive source or seed. Addition of hyperthermia to brachytherapy enhances treatment in certain types of cancer, especially if it is delivered in conjunction with the radiation thera...
Muscarinic Agonists for the Treatment of Autism Spectrum Disorder
Project ID: D2011-54Background Autism Spectrum Disorder (ASD) describes a group of developmental disorders that is often characterized by persistent repetitive and restrictive behaviors and deficits in social communication that, overall, affect the ability of the individual to functional normally in a social setting. Although early treatment and ...
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