Search Results - Rare+Disease

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Treatment of Polycystic Kidney Disease using Muscarinic Acetylcholine Receptor Modulators

Project ID: TECH2026-01 Background Polycystic Kidney Disease (PKD) affects 1 in 500 people. Half of PKD of patients reach kidney failure by age 50. Annual U.S. healthcare costs exceed $120 billion. There is currently no cure and a few affective treatments. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by...

An Attenuated Vaccine for Lyme Disease

Project ID: TECH2026-05 Background Lyme disease is caused by the gram-negative spirochete Borrelia burgdorferi, as well as other Borrelia species within the Borrelia burgdorferi sensu lato group. B. burgdorferi is known to alter its virulence protein expression profiles depending on its environment. Numerous studies have shown environmental differences...

Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms

Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...