Search Results - Biochemistry

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Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
New Species-Selective Antimicrobials to Thwart Developing Resistance
Project ID: D2015-58IP Status: PCT patent application filedInvention Description and Novelty: Drug resistance limits the effectiveness of most currently used antimicrobial agents. Infectious organisms are becoming resistant to even the most recently developed antimicrobials that target essential steps in cell wall assembly and protein biosynthesis....
Anti-Infective Antibacterial Agents against Mycobacterium Tuberculosis and other Mycobacterium Species
Project ID: D2016-53IP Status: PCT patent application #PCT/US17/028782Invention Description and Novelty: New compound represents useful antimicrobial agents effective against human and veterinary pathogens, particularly acid-fast organisms such as Mycobacterium tuberculosis and shows improved efficacy and activity well below toxicity to human monoc...
Method to Develop Compounds for Treating Canavan Disease
Project ID: D2016-26IP Status: PCT patent application filedInvention Description and Novelty: Canavan disease is a neurological disease caused by an interruption in the metabolism of N-acetylaspartate (NAA). Numerous mutations have been found in the enzyme that hydrolyzes NAA, and the catalytic activity of aspartoacylase is significantly impaired i...