1,3-Butanediol as a therapeutic for salt-sensitive hypertension

Description:

Project ID:  D2018-47

 

Background

In many populations, salt intake is greater than the recommended 3.75 grams per day.

Excess salt consumption can lead to cardiovascular, renal, and liver problems, including high blood pressure. Exercise can naturally decrease hypertension, but can be difficult for some patients to incorporate into their life. Current medications for treating salt-sensitive hypertension target multiple organs and are ineffective to resistant hypertension. Therefore, there is a need for a more effective therapeutic for hypertension.

Invention Description

Researchers found that 1,3-Butanediol treatment lowered hypertension by increasing Betahydroxybutyrate (BHB) in a Th17 independent pathway, thereby blocking the Nlrp3 inflammasome. This also had the effect of decreasing kidney fibrosis and improving kidney function. In vivo studies demonstrated lower levels of renal Nlrp3, Casp1,  IL1b, IL18, Lcn2, etc. in high-salt diet rats treated with 1,3-butanediol. Protein casts and macrophage infiltration was also significantly lowered in kidneys of treated animals.  Also, urinary protein excretion was significantly lower in the treated animals.

 

Applications

-       Treatment for salt-sensitive hypertension

-       Nutraceutical or food additive

 

Advantages

-       Already used as a hypoglycemic agent and is approved by the FDA for human consumption

-       Betahydroxybutyrate (BHB) is a host metabolite, not a xenobiotic

-       Preclinical trials completed

 

IP Status:        Patent pending

 

Publication:       Salt-responsive Metabolite, B-hydroxybutyrate, Attenuates Hypertension. Chakraborty  S, Galla S, Cheng X, Yeo J, Mell B, Singh V, Yeoh BS, Saha P, Mathew, A, Vijay-Kumar, M, Joe B. Under preparation for review.

 

Patent Information:
Category(s):
Therapeutics
For Information, Contact:
Katherine Pollard
Licensing Associate
The University of Toledo
419-530-6228
katherine.pollard@utoledo.edu
Inventors:
Bina Joe
Saroj Chakraborty
Keywords:
1,3-butanediol
Betahydroxybutyrate
Food additive
Hypertension
Nutraceutical
Nutritional
Salt-sensitive
Supplement
Therapeutic