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Novel compounds and methods for exosome production
Project ID: D2017-25Background Exosomes are vesicles in the range of 30 to 120nm, which are released from mammalian cells when multi-vesicular endosomes fuse with the plasma membrane. In recent times, exosomes have been implicated in cancer. Mounting evidence suggests that exosomes play an important role in mediating intercellular communication wi...
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model o...
Methods for detecting exposure to cyantoxins
Project ID: D2018-46Background Harmful Algal Blooms (HAB) are becoming more frequent worldwide due to factors such as temperature increase and pollution. Microcystins (MC) are carcinogenic toxins released by the algae during a blooms. MC exposure can occur via skin contact, inhalation, and ingestion and can cause illness in people and animals. MC d...
Novel Method for Reverse Automated Nucleic Acid Synthesis
Project ID: D2017-49BackgroundAutomated processes are widely used in the synthesis of modified oligonucleotide strands. These modified oligonucleotides are useful in the treatment or investigation of various conditions and diseases. Currently, the most common subunits used to synthesize RNA strands in the 3 to 5 direction are 3 phosphoramidite...
Sensor and assay for screening of photosensitizers in living cells
Project ID: D2018-33Background Photodynamic therapy (PDT) uses light and a photosensitizer in the presence of oxygen to elicit cell death. This technique has been under investigation for use in treatment of cancerMost often used to treat skin cancer, mycosis fungoides, and non-small cell lung cancer. Researchers need to detect the ability of PDTs ...
Homogenous and Reusable Superacid Polymer Catalyst for the Synthesis of 5-Hydroxymethylfurfural from Glucose
Project ID: D2018-18Background Combinations of Brønsted and Lewis acid catalysts are generally used for the production of 5-hydroxymethylfurfural (HMF) from glucose. However, reutilization of these catalysts is challenging due to their solubility in reaction medium. Heterogeneous catalysts containing both types of acid sites are not usually...
3D Printable Bioactive Glass/Polymer Composite
Project ID: D2018-16Background Popularity of 3D printing has grown exponentially in the last decade, leading to endless applications of rapid prototyping and production of parts in a variety of fields such as aerospace and medicine. In any application, it is critical that the appropriate printing material is selected to ensure proper function and ...
Novel Composite Sensor for Detecting Free Radicals
Project ID: D2017-31Background Reactive oxygen species (ROS) detection and measurement is frequently practiced in a broad range of medical and clinical settings. Free radicals are known to cause and/or exacerbate illnesses including cancer and neurodegenerative diseases. Currently, ROS detection includes free radical trapping and fingerprinting me...
Treatment of Ischemic Stroke with ROS-Sensitive Nitric Oxide Synthase Inhibitors
Project ID: D2018-11Background Nearly 800,000 people in the United States suffer a stroke every year, with about 87% of the strokes being classified as ischemic. Ischemic stroke is caused by blockage of blood flow to the brain, which results in neuronal and glial hypoxia and, subsequently, inflammatory and free radical-mediated cell death. Reactive...
Anti-Beta-Catenin (5H10) Monoclonal Antibody
Project #: D1995-12e Antigen Specificity: Beta – catenin Clone: 5H10 Specificity: Reacts with ~92 kDa β-catenin protein Host species: Mouse Reactive species: Human, Mouse, Chicken Description: 5H10 monoclonal antibody reacts with beta-catenin protein, a member of a catenin family. Catenins are intracellular proteins that interact...
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