Search Results - Cancer

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Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Novel HDAC Inhibitors as Anti-Cancer Agents
Project: D2014-49 Background: Cancer remains the second most common cause of death, accounting for nearly 1 out of every 4 deaths in the United States. American Chemical Society has estimated diagnosis of more than 1.6 million new cancer cases and deaths of more than 500,000 cancer patients in the US in the year 2014 alone. A promising new anticanc...
Small Drug-Like Molecules as Anticancer Agents Selective for Cancer Stem Cells
Project ID: D2013-04Novelty: A new class of anticancer agents which are highly selective for mesenchymal cancer cells with stem cell like properties.Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the same time, tumors are heterogeneous and curre...
Advancement in Platinum Based Cancer Therapeutics
Project ID: D2014-33Novelty: Small drug like molecules that inhibits DNA repair factors for cisplatin (and other platinum based drugs) resistance towards solid tumors, thereby increasing cisplatin cytotoxicity and efficacy. Value proposition: One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer c...
Injectable Biodegradable Bone Matrix for Multiple Myeloma Lesion Augmentation and Osteoporosis
Project ID: D2013-62 Invention Description and Novelty: Unique technology targets both ends of the bone remodeling process by introducing therapies to suppress osteoporosis and restore bone formation in the case of multiple myeloma and other cancer-induced bone diseases. Value proposition: ยท Unique injectable bone filler composition sets i...
Novel Epothilone Analogues as Antileukemia Agents and Method Thereof
Project ID: PHR00107 Novelty: Conformationally restrained novel epothilone analogue exhibiting strong and selective growth inhibitory effect on leukemia cell lines. Background: Epothilones have been reported to exhibit potent anticancer activity and a number of epothilone analogs have entered clinical evaluation in humans (in addition to Epo B),...
Novel Non-ATP Competitive SRC Inhibitor for Treating Cancer
Project ID: D2009-07Background:P SRC kinase inhibitors have been clinically tested on a number of cancers. These inhibitors work by interrupting SRC’s role in tumor growth, proliferation, adhesion and motility. The most common method of inhibiting SRC is through an ATP analog, blocking the ATP binding site. However, ATP analogs have relat...
Engineered Protein Tames Bleeding In Haemophiliacs and Targets Angiogenesis in Cancer
Project ID: D2007-12 U.S. Patent #8,211,858; Canada, European patents pending U.S. Patent #7,592,422; Canada, France, Germany, Netherlands, UK patents pending Novelty: Modified plasminogen activator inhibitor type I (PAI- 1) with significantly increased in vivo half-life and decreased activity to urokinase plasminogen activator, tissue plasminog...
Novel Peptides: Effective Therapeutics for Late Stage Prostate and Other EZH2-Dependent Cancers
Project ID: D2009-27Background: Prostate cancer, the second leading cause of cancer deaths among men, largely depends upon androgens for its development and progression. The importance of the Androgen Receptor in the development of prostate cancer is demonstrated by the success of anti-androgen therapy at the early stages of prostate cancer. Hormo...