Search Results - Biotechnology

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Synthesis of Novel Calcium Phosphate Nanowhiskers
Project ID: D2011-31 Background: Viral gene delivery techniques are among the most commonly used gene delivery techniques owing to their high reported efficiencies. The primary drawback of viral gene delivery results from the risks associated with insertional mutagenesis. In some instances, such therapies have resulted in patient death after the ...
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Furoxans as Novel Therapeutics for Neurodegenerative Disorders
Project ID: D2017-15Invention Description:Nitric oxide (NO) signaling is essential for brain activity and normal neuronal function. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetics, such as nitrates, have been implicated for use against a variety of neurological disorders, in...
Use of Small Molecule Inhibitors as Anti-Thrombotic Agents
Project: D2016-03IP Status: PCT filed Invention Description: Discovery of a new family of small molecules that can be used to decrease the risk of thrombosis in patients with several diseases. Novelty: The most important aspect of this new antithrombotic is that it prevents the transition of platelets to a hypersensitive state without impacting nor...
Loading Platform for Three-Dimensional Tissue Engineering Scaffolds
Project ID: D2016-48 IP Status: PCT patent application # PCT/US17/020706 Applications: Three-dimensional loading platform for mechanical stimulation of cellular scaffolds for pharmaceuticals and tissue engineering strategies.Invention Description and Novelty: Innovative method of handling and transfer of mechanical strains to tissue engineering sc...
Biomimetic approach to deposit bone-like coating on PEEK and other materials to improve osteoconductivity in implants
Project ID: D2011-33IP Status: Patent Pending U.S and EuropeInvention Description: Novel method to prepare an implantable article comprised of a biocompatible substrate (polymeric or ceramic) to accept a very thin biocompatible, bioactive coating material to facilitate bio-ingrowth between the substrate and bone or cartilage tissue.Applications: Bo...
Generation of Stable iTregs as Therapeutics against Autoimmune Diseases (Type I Diabetes)
Project ID: D2010-30 Invention novelty: New methods for induction and expansion of stable iTregs without addition of exogenous TGF-βValue Proposition: The “anti-self” immune response in human body leads to development of autoimmune diseases. For example, Diabetes mellitus type 1 (formerly known as juvenile diabetes) results from au...
Advancement in Platinum Based Cancer Therapeutics
Project ID: D2014-33Novelty: Small drug like molecules that inhibits DNA repair factors for cisplatin (and other platinum based drugs) resistance towards solid tumors, thereby increasing cisplatin cytotoxicity and efficacy. Value proposition: One of the limitations of chemotherapy in ovarian cancer is the innate/acquired drug resistance in cancer c...
Amine-terminated Aptamer Functionalized SPR Sensor
Project ID: D2012-07 IP Status: Provisional Application Invention novelty and description: This novel invention describes sensors for target entities having at least one amine-terminated aptamer specific to the target entity. Aptamers are artificial oligonucleotides which can serve as antibody mimics because of their high affinity and selectivity ...
Highly sensitive portable technique for detecting wide variety of biological analytes
Project ID: PHYS00304 IP Status: Issued U.S. Utility Patent 8,143,072 Invention novelty and description: Novel technology offers a sensitive and broadly applicable system to detect magneto-optical and plasmon-like resonance properties of magnetic nanoparticles (MNP), dosed MNPs and biological analytes using optical or magneto-optical reflection, t...
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